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          Institute: MPI für molekulare Biomedizin     Collection: Jahrbuch 2017 (publ. 2016, arch)     Display Documents



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ID: 732152.0, MPI für molekulare Biomedizin / Jahrbuch 2017 (publ. 2016, arch)
Regulation of monocyte cell fate by blood vessels mediated by Notch signalling
Authors:Gamrekelashvili, J.; Giagnorio, R.; Jussofie, J.; Soehnlein, O.; Duchene, J.; Briseno, C. G.; Ramasamy, S. K.; Krishnasamy, K.; Limbourg, A.; Kapanadze, T.; Ishifune, C.; Hinkel, R.; Radtke, F.; Strobl, L. J.; Zimber-Strobl, U.; Napp, L. C.; Bauersachs, J.; Haller, H.; Yasutomo, K.; Kupatt, C.; Murphy, K. M.; Adams, R. H.; Weber, C.; Limbourg, F. P.
Date of Publication (YYYY-MM-DD):2016-08
Title of Journal:Nat Commun
Volume:7
Start Page:14
Review Status:Internal review
Audience:Not Specified
Abstract / Description:A population of monocytes, known as Ly6C(lo) monocytes, patrol blood vessels by crawling along the vascular endothelium. Here we show that endothelial cells control their origin through Notch signalling. Using combinations of conditional genetic deletion strategies and cell-fate tracking experiments we show that Notch2 regulates conversion of Ly6C(hi) monocytes into Ly6C(lo) monocytes in vivo and in vitro, thereby regulating monocyte cell fate under steady-state conditions. This process is controlled by Notch ligand delta-like 1 (Dll1) expressed by a population of endothelial cells that constitute distinct vascular niches in the bone marrow and spleen in vivo, while culture on recombinant DLL1 induces monocyte conversion in vitro. Thus, blood vessels regulate monocyte conversion, a form of committed myeloid cell fate regulation.
Free Keywords:hematopoietic stem-cells; green fluorescent protein; dendritic cells; postnatal arteriogenesis; classical monocytes; lineage commitment; angiocrine factors; endothelial-cells; vascular niche; lymph-nodes; Science & Technology - Other Topics
External Publication Status:published
Document Type:Article
Communicated by:Jeanine Müller-Keuker
Affiliations:MPI für molekulare Biomedizin
External Affiliations:Limbourg, FP (reprint author), Hannover Med Sch, Dept Hypertens & Nephrol, D-30625 Hannover, Germany.; Limbourg, FP (reprint author), Hannover Med Sch, Integrated Res & Treatment Ctr Transplantat, D-30625 Hannover, Germany. limbourg.florian@mh-hannover.de %G English
Identifiers:ISSN:2041-1723 %R 10.1038/ncomms12597 %] 12597 [ID No:1]
URL:<Go to ISI>://WOS:000391871000001 [ID No:2]
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