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          Institute: MPI für molekulare Biomedizin     Collection: Jahrbuch 2017 (publ. 2016, arch)     Display Documents



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ID: 732161.0, MPI für molekulare Biomedizin / Jahrbuch 2017 (publ. 2016, arch)
Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII
Authors:Chu, M.; Li, T. T.; Shen, B.; Cao, X. D.; Zhong, H. Y.; Zhang, L. Q.; Zhou, F.; Ma, W. J.; Jiang, H. J.; Xie, P. C.; Liu, Z. Z.; Dong, N. Z.; Xu, Y.; Zhao, Y.; Xu, G. Q.; Lu, P. R.; Luo, J. C.; Wu, Q. Y.; Alitalo, K.; Koh, G. Y.; Adams, R. H.; He, Y. L.
Date of Publication (YYYY-MM-DD):2016-12
Title of Journal:eLife
Volume:5
Start Page:16
Review Status:Internal review
Audience:Not Specified
Abstract / Description:Mechanisms underlying the vein development remain largely unknown. Tie2 signaling mediates endothelial cell (EC) survival and vascular maturation and its activating mutations are linked to venous malformations. Here we show that vein formation are disrupted in mouse skin and mesentery when Tie2 signals are diminished by targeted deletion of Tek either ubiquitously or specifically in embryonic ECs. Postnatal Tie2 attenuation resulted in the degeneration of newly formed veins followed by the formation of haemangioma-like vascular tufts in retina and venous tortuosity. Mechanistically, Tie2 insufficiency compromised venous EC identity, as indicated by a significant decrease of COUP-TFII protein level, a key regulator in venogenesis. Consistently, angiopoietin-1 stimulation increased COUP-TFII in cultured ECs, while Tie2 knockdown or blockade of Tie2 downstream PI3K/Akt pathway reduced COUP-TFII which could be reverted by the proteasome inhibition. Together, our results imply that Tie2 is essential for venous specification and maintenance via Akt mediated stabilization of COUP-TFII.
Free Keywords:arterial specification; venous differentiation; vascular development; tyrosine kinases; tip cells; mouse; angiogenesis; expression; pathway; mice; Life Sciences & Biomedicine - Other Topics
External Publication Status:published
Document Type:Article
Communicated by:Jeanine Müller-Keuker
Affiliations:MPI für molekulare Biomedizin
External Affiliations:He, YL (reprint author), Soochow Univ, Collaborat Innovat Ctr Hematol, Cyrus Tang Hematol Ctr, Suzhou, Peoples R China.; He, YL (reprint author), Soochow Univ, Cam Su Genom Resources Ctr, Suzhou, Peoples R China.; He, YL (reprint author), Soochow Univ, Affiliated Hosp 1, Jiangsu Inst Hematol, Suzhou, Peoples R China.; He, YL (reprint author), Soochow Univ, Jiangsu Key Lab Prevent & Translat Med Geriatr Di, Suzhou, Peoples R China. heyulong@suda.edu.cn %G English
Identifiers:ISSN:2050-084X %R 10.7554/eLife.21032 %] e21032 [ID No:1]
URL:<Go to ISI>://WOS:000394246100001 [ID No:2]
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