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          Institute: MPI für molekulare Biomedizin     Collection: Jahrbuch 2017 (publ. 2016, arch)     Display Documents

ID: 732164.0, MPI für molekulare Biomedizin / Jahrbuch 2017 (publ. 2016, arch)
Endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells
Authors:Chen, Q.; Zhang, H.; Liu, Y.; Adams, S.; Eilken, H.; Stehling, M.; Corada, M.; Dejana, E.; Zhou, B.; Adams, R. H.
Date of Publication (YYYY-MM-DD):2016-08
Title of Journal:Nat Commun
Start Page:13
Review Status:Internal review
Audience:Not Specified
Abstract / Description:Mural cells of the vessel wall, namely pericytes and vascular smooth muscle cells, are essential for vascular integrity. The developmental sources of these cells and molecular mechanisms controlling their progenitors in the heart are only partially understood. Here we show that endocardial endothelial cells are progenitors of pericytes and vascular smooth muscle cells in the murine embryonic heart. Endocardial cells undergo endothelial-mesenchymal transition and convert into primitive mesenchymal progenitors expressing the platelet-derived growth factor receptors, PDGFR alpha and PDGFR beta. These progenitors migrate into the myocardium, differentiate and assemble the wall of coronary vessels, which requires canonical Wnt signalling involving Frizzled4, beta-catenin and endothelial cell-derived Wnt ligands. Our findings identify a novel and unexpected population of progenitors for coronary mural cells with potential relevance for heart function and disease conditions.
Free Keywords:to-mesenchymal transition; neural crest origin; blood-brain-barrier; stem-cells; aortic endothelium; coronary-arteries; capillary pericytes; beta-catenin; adult thymus; in-vivo; Science & Technology - Other Topics
External Publication Status:published
Document Type:Article
Communicated by:Jeanine Müller-Keuker
Affiliations:MPI für molekulare Biomedizin
External Affiliations:Adams, RH (reprint author), Univ Munster, Dept Tissue Morphogenesis, Fac Med, Max Planck Inst Mol Biomed, D-48149 Munster, Germany. %G English
Identifiers:ISSN:2041-1723 %R 10.1038/ncomms12422 %] 12422 [ID No:1]
URL:<Go to ISI>://WOS:000381526500001 [ID No:2]
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