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          Institute: MPI für molekulare Biomedizin     Collection: Jahrbuch 2017 (publ. 2016, arch)     Display Documents



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ID: 732168.0, MPI für molekulare Biomedizin / Jahrbuch 2017 (publ. 2016, arch)
Pivotal role for skin transendothelial radio-resistant anti-inflammatory macrophages in tissue repair
Authors:Barreiro, O.; Cibrian, D.; Clemente, C.; Alvarez, D.; Moreno, V.; Valiente, I.; Bernad, A.; Vestweber, D.; Arroyo, A. G.; Martin, P.; von Andrian, U. H.; Sanchez Madrid, F.
Date of Publication (YYYY-MM-DD):2016-06-15
Title of Journal:eLife
Volume:5
Review Status:Internal review
Audience:Not Specified
Abstract / Description:Heterogeneity and functional specialization among skin-resident macrophages are incompletely understood. In this study, we describe a novel subset of murine dermal perivascular macrophages that extend protrusions across the endothelial junctions in steady-state and capture blood-borne macromolecules. Unlike other skin-resident macrophages that are reconstituted by bone marrow-derived progenitors after a genotoxic insult, these cells are replenished by an extramedullary radio-resistant and UV-sensitive Bmi1(+) progenitor. Furthermore, they possess a distinctive anti-inflammatory transcriptional profile, which cannot be polarized under inflammatory conditions, and are involved in repair and remodeling functions for which other skin-resident macrophages appear dispensable. Based on all their properties, we define these macrophages as Skin Transendothelial Radio-resistant Anti-inflammatory Macrophages (STREAM) and postulate that their preservation is important for skin homeostasis.
Free Keywords:immunology; intravital imaging; macrophages; mouse; wound healing
External Publication Status:published
Document Type:Article
Communicated by:Jeanine Müller-Keuker
Affiliations:MPI für molekulare Biomedizin
External Affiliations:Servicio de Inmunologia, Hospital de la Princesa, Universidad Autonoma de Madrid, Madrid, Spain. Instituto Investigacion Sanitaria Princesa, Universidad Autonoma de Madrid, Madrid, Spain. Department of Microbiology and Immunobiology, Harvard Medical School, Boston, United States. Department of Cardiovascular Development and Repair, Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain. Max Planck Institute of Molecular Biomedicine, Munster, Germany. Ragon Institute of MGH, MIT and Harvard, Cambridge, United States.
Identifiers:ISSN:2050-084X (Electronic) 2050-084X (Linking) %R 10.7... [ID No:1]
URL:http://www.ncbi.nlm.nih.gov/pubmed/27304075 [ID No:2]
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