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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: MPI-CBG Publications 2016 (archival)     Display Documents



ID: 732361.0, MPI für molekulare Zellbiologie und Genetik / MPI-CBG Publications 2016 (archival)
A pH-driven transition of the cytoplasm from a fluid- to a solid-like state promotes entry into dormancy.
Authors:Munder, Matthias; Midtvedt, Daniel; Franzmann, Titus; Nüske, Elisabeth; Otto, Oliver; Herbig, Maik; Ulbricht, Elke; Müller, Paul; Taubenberger, Anna; Maharana, Shovamayee; Malinovska, Liliana; Richter, Doris; Guck, Jochen; Zaburdaev, Vasily; Alberti, Simon
Date of Publication (YYYY-MM-DD):2016
Title of Journal:eLife
Volume:5
Sequence Number of Article:e09347
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Cells can enter into a dormant state when faced with unfavorable conditions. However, how cells enter into and recover from this state is still poorly understood. Here, we study dormancy in different eukaryotic organisms and find it to be associated with a significant decrease in the mobility of organelles and foreign tracer particles. We show that this reduced mobility is caused by an influx of protons and a marked acidification of the cytoplasm, which leads to widespread macromolecular assembly of proteins and triggers a transition of the cytoplasm to a solid-like state with increased mechanical stability. We further demonstrate that this transition is required for cellular survival under conditions of starvation. Our findings have broad implications for understanding alternative physiological states, such as quiescence and dormancy, and create a new view of the cytoplasm as an adaptable fluid that can reversibly transition into a protective solid-like state.
External Publication Status:published
Document Type:Article
Communicated by:Thüm
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:6478
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