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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: MPI-CBG Publications 2016 (archival)     Display Documents



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ID: 732379.0, MPI für molekulare Zellbiologie und Genetik / MPI-CBG Publications 2016 (archival)
NAD+ Is a Food Component That Promotes Exit from Dauer Diapause in Caenorhabditis elegans.
Authors:Mylenko, Mykola; Boland, Sebastian; Penkov, Sider; Sampaio, Julio; Lombardot, Benoit; Vorkel, Daniela; Verbavatz, Jean-Marc; Kurzchalia, Teymuras V.
Date of Publication (YYYY-MM-DD):2016
Title of Journal:PLoS ONE
Volume:11
Issue / Number:12
Sequence Number of Article:e0167208
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:The free-living soil nematode Caenorhabditis elegans adapts its development to the availability of food. When food is scarce and population density is high, worms enter a developmentally arrested non-feeding diapause stage specialized for long-term survival called the dauer larva. When food becomes available, they exit from the dauer stage, resume growth and reproduction. It has been postulated that compound(s) present in food, referred to as the "food signal", promote exit from the dauer stage. In this study, we have identified NAD+ as a component of bacterial extract that promotes dauer exit. NAD+, when dissolved in alkaline medium, causes opening of the mouth and ingestion of food. We also show that to initiate exit from the dauer stage in response to NAD+ worms require production of serotonin. Thus, C. elegans can use redox cofactors produced by dietary organisms to sense food.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Thüm
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:6720
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