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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: MPI-CBG Publications 2016 (archival)     Display Documents



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ID: 732392.0, MPI für molekulare Zellbiologie und Genetik / MPI-CBG Publications 2016 (archival)
Signal processing by the endosomal system.
Authors:Villaseñor, Roberto; Kalaidzidis, Yannis; Zerial, Marino
Date of Publication (YYYY-MM-DD):2016
Title of Journal:Current Opinion in Cell Biology
Volume:39
Start Page:53
End Page:60
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Cells need to decode chemical or physical signals from their environment in order to make decisions on their fate. In the case of signalling receptors, ligand binding triggers a cascade of chemical reactions but also the internalization of the activated receptors in the endocytic pathway. Here, we highlight recent studies revealing a new role of the endosomal network in signal processing. The diversity of entry pathways and endosomal compartments is exploited to regulate the kinetics of receptor trafficking, and interactions with specific signalling adaptors and effectors. By governing the spatio-temporal distribution of signalling molecules, the endosomal system functions analogously to a digital-analogue computer that regulates the specificity and robustness of the signalling response.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Thüm
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:6454
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