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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: MPI-CBG Publications 2016 (archival)     Display Documents

ID: 732414.0, MPI für molekulare Zellbiologie und Genetik / MPI-CBG Publications 2016 (archival)
Forebrain-specific loss of synaptic GABAA receptors results in altered neuronal excitability and synaptic plasticity in mice.
Authors:O'Sullivan, Gregory A; Jedlicka, Peter; Chen, Hong-Xing; Kalbouneh, Heba; Ippolito, Angelo; Deller, Thomas; Nawrotzki, Ralph A; Kuhse, Jochen; Kalaidzidis, Yannis; Kirsch, Joachim; Schwarzacher, Stephan W; Betz, Heinrich
Date of Publication (YYYY-MM-DD):2016
Title of Journal:Molecular and Cellular Neurosciences
Start Page:101
End Page:113
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Mutations that result in the defective trafficking of γ2 subunit containing GABAA receptors (γ2-GABAARs) are known to reduce synaptic inhibition. Whether perturbed clustering of non-mutated GABAARs similarly reduces synaptic inhibition in vivo is less clear. In this study we provide evidence that the loss of postsynaptic γ2-GABAARs upon postnatal ablation of gephyrin, the major scaffolding protein of inhibitory postsynapses, from mature principal neurons within the forebrain results in reduced induction of long-term potentiation (LTP) and impaired network excitability within the hippocampal dentate gyrus. The preferential reduction in not only synaptic γ2-GABAAR cluster number at dendritic sites but also the decrease in γ2-GABAAR density within individual clusters at dendritic inhibitory synapses suggests that distal synapses are more sensitive to the loss of gephyrin expression than proximal synapses. The fact that these mice display behavioural features of anxiety and epilepsy emphasises the importance of postsynaptic γ2-GABAAR clustering for synaptic inhibition.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Thüm
Affiliations:MPI für molekulare Zellbiologie und Genetik
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