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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: MPI-CBG Publications 2016 (archival)     Display Documents

ID: 732429.0, MPI für molekulare Zellbiologie und Genetik / MPI-CBG Publications 2016 (archival)
The glyoxylate shunt is essential for desiccation tolerance in C. elegans and budding yeast.
Authors:Erkut, Cihan; Gade, Vamshidhar; Laxman, Sunil; Kurzchalia, Teymuras V.
Date of Publication (YYYY-MM-DD):2016
Title of Journal:eLife
Sequence Number of Article:e13614
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Many organisms, including species from all kingdoms of life, can survive desiccation by entering a state with no detectable metabolism. To survive, C. elegans dauer larvae and stationary phase S. cerevisiae require elevated amounts of the disaccharide trehalose. We found that that dauer larvae and stationary phase yeast switched into a gluconeogenic mode in which metabolism was reoriented toward production of sugars from non-carbohydrate sources. This mode depended on full activity of the glyoxylate shunt (GS), which enables synthesis of trehalose from acetate. The GS was especially critical during preparation of worms for harsh desiccation (preconditioning) and during the entry of yeast into stationary phase. Loss of the GS dramatically decreased desiccation tolerance in both organisms. Our results reveal a novel physiological role for the GS and elucidate a conserved metabolic rewiring that confers desiccation tolerance on organisms as diverse as worm and yeast.
External Publication Status:published
Document Type:Article
Communicated by:Thüm
Affiliations:MPI für molekulare Zellbiologie und Genetik
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