| ID:
732439.0,
MPI für molekulare Zellbiologie und Genetik / MPI-CBG Publications 2016 (archival) |
| Stochastic resetting in backtrack recovery by RNA polymerases. |
| Authors: | Roldán, Édgar; Lisica, Ana; Sánchez-Taltavull, Daniel; Grill, Stephan W. |
| Date of Publication (YYYY-MM-DD): | 2016 |
| Title of Journal: | Physical Review. E |
| Volume: | 93 |
| Issue / Number: | 6-1 |
| Sequence Number of Article: | 062411 |
| Copyright: | not available |
| Audience: | Experts Only |
| Intended Educational Use: | No |
| Abstract / Description: | Transcription is a key process in gene expression, in which RNA polymerases produce a complementary RNA copy from a DNA template. RNA polymerization is frequently interrupted by backtracking, a process in which polymerases perform a random walk along the DNA template. Recovery of polymerases from the transcriptionally inactive backtracked state is determined by a kinetic competition between one-dimensional diffusion and RNA cleavage. Here we describe backtrack recovery as a continuous-time random walk, where the time for a polymerase to recover from a backtrack of a given depth is described as a first-passage time of a random walker to reach an absorbing state. We represent RNA cleavage as a stochastic resetting process and derive exact expressions for the recovery time distributions and mean recovery times from a given initial backtrack depth for both continuous and discrete-lattice descriptions of the random walk. We show that recovery time statistics do not depend on the discreteness of the DNA lattice when the rate of one-dimensional diffusion is large compared to the rate of cleavage. |
| External Publication Status: | published |
| Document Type: | Article |
| Version Comment: | Automatic journal name synchronization |
| Communicated by: | Thüm |
| Affiliations: | MPI für molekulare Zellbiologie und Genetik
|
| Identifiers: | LOCALID:6584 |
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