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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: MPI-CBG Publications 2016 (archival)     Display Documents



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ID: 732455.0, MPI für molekulare Zellbiologie und Genetik / MPI-CBG Publications 2016 (archival)
The F-actin modifier villin regulates insulin granule dynamics and exocytosis downstream of islet cell autoantigen 512.
Authors:Mziaut, Hassan; Mulligan, Bernard; Hoboth, Peter; Otto, Oliver; Ivanova, Anna; Herbig, Maik; Schumann, Desiree; Hildebrandt, Tobias; Dehghany, J; Sönmez, Anke; Münster, Carla; Meyer-Hermann, M; Guck, Jochen; Kalaidzidis, Yannis; Solimena, Michele
Date of Publication (YYYY-MM-DD):2016
Title of Journal:Molecular Metabolism
Volume:5
Issue / Number:8
Start Page:656
End Page:668
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Insulin release from pancreatic islet β cells should be tightly controlled to avoid hypoglycemia and insulin resistance. The cortical actin cytoskeleton is a gate for regulated exocytosis of insulin secretory granules (SGs) by restricting their mobility and access to the plasma membrane. Prior studies suggest that SGs interact with F-actin through their transmembrane cargo islet cell autoantigen 512 (Ica512) (also known as islet antigen 2/Ptprn). Here we investigated how Ica512 modulates SG trafficking and exocytosis.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Thüm
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:6689
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