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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: MPI-CBG Publications 2016 (archival)     Display Documents



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ID: 732470.0, MPI für molekulare Zellbiologie und Genetik / MPI-CBG Publications 2016 (archival)
Actomyosin-driven left-right asymmetry: from molecular torques to chiral self organization.
Authors:Naganathan, Sundar; Middelkoop, Teije C; Fürthauer, Sebastian; Grill, Stephan W.
Date of Publication (YYYY-MM-DD):2016
Title of Journal:Current Opinion in Cell Biology
Volume:38
Start Page:24
End Page:30
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Chirality or mirror asymmetry is a common theme in biology found in organismal body plans, tissue patterns and even in individual cells. In many cases the emergence of chirality is driven by actin cytoskeletal dynamics. Although it is well established that the actin cytoskeleton generates rotational forces at the molecular level, we are only beginning to understand how this can result in chiral behavior of the entire actin network in vivo. In this review, we will give an overview of actin driven chiralities across different length scales known until today. Moreover, we evaluate recent quantitative models demonstrating that chiral symmetry breaking of cells can be achieved by properly aligning molecular-scale torque generation processes in the actomyosin cytoskeleton.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Thüm
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:6443
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