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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: MPI-CBG Publications 2016 (archival)     Display Documents



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ID: 732477.0, MPI für molekulare Zellbiologie und Genetik / MPI-CBG Publications 2016 (archival)
Loss of Trex1 in Dendritic Cells Is Sufficient To Trigger Systemic Autoimmunity.
Authors:Peschke, Katrin; Achleitner, Martin; Frenzel, Kathrin; Gerbaulet, Alexander; Ada, Servi Remzi; Zeller, Nicolas; Lienenklaus, Stefan; Lesche, Mathias; Poulet, Claire; Naumann, Ronald; Dahl, Andreas; Ravens, Ursula; Günther, Claudia; Müller, Werner; Knobeloch, Klaus-Peter; Prinz, Marco; Roers, Axel; Behrendt, Rayk
Date of Publication (YYYY-MM-DD):2016
Title of Journal:Journal of Immunology (Baltimore, Md. : 1950)
Volume:197
Issue / Number:6
Start Page:2157
End Page:2166
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Defects of the intracellular enzyme 3' repair exonuclease 1 (Trex1) cause the rare autoimmune condition Aicardi-Goutières syndrome and are associated with systemic lupus erythematosus. Trex1(-/-) mice develop type I IFN-driven autoimmunity, resulting from activation of the cytoplasmic DNA sensor cyclic GMP-AMP synthase by a nucleic acid substrate of Trex1 that remains unknown. To identify cell types responsible for initiation of autoimmunity, we generated conditional Trex1 knockout mice. Loss of Trex1 in dendritic cells was sufficient to cause IFN release and autoimmunity, whereas Trex1-deficient keratinocytes and microglia produced IFN but did not induce inflammation. In contrast, B cells, cardiomyocytes, neurons, and astrocytes did not show any detectable response to the inactivation of Trex1. Thus, individual cell types differentially respond to the loss of Trex1, and Trex1 expression in dendritic cells is essential to prevent breakdown of self-tolerance ensuing from aberrant detection of endogenous DNA.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Thüm
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:6623
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