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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: MPI-CBG Publications 2016 (archival)     Display Documents



  history
ID: 732507.0, MPI für molekulare Zellbiologie und Genetik / MPI-CBG Publications 2016 (archival)
The endosomal transcriptional regulator RNF11 integrates degradation and transport of EGFR.
Authors:Scharaw, Sandra; Iskar, Murat; Ori, Alessandro; Boncompain, Gaelle; Laketa, Vibor; Poser, Ina; Lundberg, Emma; Perez, Franck; Beck, Mike; Bork, Peer; Pepperkok, Rainer
Date of Publication (YYYY-MM-DD):2016
Title of Journal:The Journal of Cell Biology
Volume:215
Issue / Number:4
Start Page:543
End Page:558
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Stimulation of cells with epidermal growth factor (EGF) induces internalization and partial degradation of the EGF receptor (EGFR) by the endo-lysosomal pathway. For continuous cell functioning, EGFR plasma membrane levels are maintained by transporting newly synthesized EGFRs to the cell surface. The regulation of this process is largely unknown. In this study, we find that EGF stimulation specifically increases the transport efficiency of newly synthesized EGFRs from the endoplasmic reticulum to the plasma membrane. This coincides with an up-regulation of the inner coat protein complex II (COPII) components SEC23B, SEC24B, and SEC24D, which we show to be specifically required for EGFR transport. Up-regulation of these COPII components requires the transcriptional regulator RNF11, which localizes to early endosomes and appears additionally in the cell nucleus upon continuous EGF stimulation. Collectively, our work identifies a new regulatory mechanism that integrates the degradation and transport of EGFR in order to maintain its physiological levels at the plasma membrane.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Thüm
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:6744
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