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          Institute: MPI für Entwicklungsbiologie     Collection: Abteilung 1 - Protein Evolution (A. Lupas)     Display Documents



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ID: 732960.0, MPI für Entwicklungsbiologie / Abteilung 1 - Protein Evolution (A. Lupas)
Coiled Coils - A Model System for the 21st Century
Authors:Lupas, A. N.; Bassler, J.
Date of Publication (YYYY-MM-DD):2017-02
Title of Journal:Trends Biochem Sci
Volume:42
Issue / Number:2
Start Page:130
End Page:140
Review Status:Internal review
Audience:Not Specified
Abstract / Description:alpha-Helical coiled coils were described more than 60 years ago as simple, repetitive structures mediating oligomerization and mechanical stability. Over the past 20 years, however, they have emerged as one of the most diverse protein folds in nature, enabling many biological functions beyond mechanical rigidity, such as membrane fusion, signal transduction, and solute transport. Despite this great diversity, their structures can be described by parametric equations, making them uniquely suited for rational protein design. Far from having been exhausted as a source of structural insight and a basis for functional engineering, coiled coils are poised to become even more important for protein science in the coming decades.
Free Keywords:coiled coil; diversity; protein design; structure
External Publication Status:published
Document Type:Article
Affiliations:MPI für Entwicklungsbiologie/Abteilung 1 - Proteinevolution (Andrei Lupas)
External Affiliations:Department of Protein Evolution, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany.
Identifiers:ISSN:0968-0004 (Print) 0968-0004 (Linking) %R 10.1016/j... [ID No:1]
URL:https://www.ncbi.nlm.nih.gov/pubmed/27884598 [ID No:2]
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