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          Institute: MPI für Entwicklungsbiologie     Collection: Abteilung 4 - Evolutionary Biology (R. Sommer)     Display Documents

ID: 733043.0, MPI für Entwicklungsbiologie / Abteilung 4 - Evolutionary Biology (R. Sommer)
Gene silencing and sex determination by programmed DNA elimination in parasitic nematodes
Authors:Streit, A.; Wang, J. B.; Kang, Y. Y.; Davis, R. E.
Date of Publication (YYYY-MM-DD):2016-08
Title of Journal:Current Opinion in Microbiology
Start Page:120
End Page:127
Review Status:Internal review
Audience:Not Specified
Abstract / Description:Maintenance of genome integrity is essential. However, programmed DNA elimination removes specific DNA sequences from the genome during development. DNA elimination occurs in unicellular ciliates and diverse metazoa ranging from nematodes to vertebrates. Two distinct groups of nematodes use DNA elimination to silence germline-expressed genes in the soma (ascarids) or for sex determination (Strongyloides spp.). Data suggest that DNA elimination likely evolved independently in these nematodes. Recent studies indicate that differential CENP-A deposition within chromosomes defines which sequences are retained and lost during Ascaris DNA elimination. Additional studies are needed to determine the distribution, functions, and mechanisms of DNA elimination in nematodes.
Free Keywords:chromatin diminution; caenorhabditis-elegans; parastrongyloides-trichosuri; strongyloides-papillosus; holocentric chromosomes; kinetochore function; telomere formation; ascaris-suum; evolution; organization
External Publication Status:published
Document Type:Article
Communicated by:MPI für Entwickungsbiologie
Affiliations:MPI für Entwicklungsbiologie/Abteilung 4 - Evolutionsbiologie (Ralf J. Sommer)
External Affiliations:Univ Colorado, Sch Med, Dept Biochem & Mol Genet, Aurora, CO 80045 USA %G English
Identifiers:ISSN:1369-5274 %R 10.1016/j.mib.2016.05.012 [ID No:1]
URL:<Go to ISI>://WOS:000382344700022 [ID No:2]
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