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          Institute: MPI für Entwicklungsbiologie     Collection: Abteilung 4 - Evolutionary Biology (R. Sommer)     Display Documents



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ID: 733061.0, MPI für Entwicklungsbiologie / Abteilung 4 - Evolutionary Biology (R. Sommer)
The genomic basis of parasitism in the Strongyloides clade of nematodes
Authors:Hunt, V. L.; Tsai, I. J.; Coghlan, A.; Reid, A. J.; Holroyd, N.; Foth, B. J.; Tracey', A.; Cotton', J. A.; Stanley, E. J.; Beasley, H.; Bennett, H. M.; Brooks, K.; Harsha, B.; Kajitani, R.; Kulkarni, A.; Harbecke, D.; Nagayasu, E.; Nichol, S.; Ogura, Y.; Quail, M. A.; Randle, N.; Xia, D.; Brattig, N. W.; Soblik, H.; Ribeiro, D. M.; Sanchez-Flores, A.; Hayashi, T.; Itoh, T.; Denver, D. R.; Grant, W.; Stoltzfus, J. D.; Lok, J. B.; Murayama, H.; Wastling, J.; Streit, A.; Kikuchi, T.; Viney, M.; Berriman, M.
Date of Publication (YYYY-MM-DD):2016-03
Title of Journal:Nature Genetics
Volume:48
Issue / Number:3
Start Page:299
End Page:307
Review Status:Internal review
Audience:Not Specified
Abstract / Description:Soil-transmitted nematodes, including the Strongyloides genus, cause one of the most prevalent neglected tropical diseases. Here we compare the genomes of four Strongyloides species, including the human pathogen Strongyloides stercoralis, and their close relatives that are facultatively parasitic (Parastrongyloides frichosuri) and free-living (Rhabditophanes sp. KR3021). A significant paralogous expansion of key gene families families encoding astacin-like and SCP/TAPS proteins is associated with the evolution of parasitism in this Glade. Exploiting the unique Strongyloides life cycle, we compare the transcriptomes of the parasitic and free-living stages and find that these same gene families are upregulated in the parasitic stages, underscoring their role in nematode parasitism.
Free Keywords:mitochondrial genome; parastrongyloides-trichosuri; haemonchus-contortus; chromatin diminution; intestinal nematode; ancylostoma-caninum; genus strongyloides; aspartic proteases; necator-americanus; globodera-pallida
External Publication Status:published
Document Type:Article
Communicated by:MPI für Entwickungsbiologie
Affiliations:MPI für Entwicklungsbiologie/Abteilung 4 - Evolutionsbiologie (Ralf J. Sommer)
External Affiliations:Acad Sinica, Biodivers Res Ctr, Taipei 115, Taiwan Miyazaki Univ, Fac Med, Div Parasitol, Miyazaki, Japan Wellcome Trust Sanger Inst, Wellcome Trust Genome Campus, Hinxton, England Tokyo Inst Technol, Grad Sch Biosci & Biotechnol, Meguro Ku, Tokyo 152, Japan Max Planck Inst Dev Biol, Tubingen, Germany Kyushu Univ, Fac Med Sci, Dept Bacteriol, Fukuoka 812, Japan Univ Liverpool, Dept Infect Biol, Inst Infect & Global Hlth, Liverpool L69 3BX, Merseyside, England Univ Liverpool, Sch Vet Sci, Liverpool L69 3BX, Merseyside, England Bernhard Nocht Inst Trop Med, Dept Mol Med, Bernhard Nocht Str 74, D-20359 Hamburg, Germany Univ Nacl Autonoma Mexico, Inst Biotecnol, Unidad Secuenciac Masiva & Bioinformat, Cuernavaca 62191, Morelos, Mexico Oregon State Univ, Dept Integrat Biol, Corvallis, OR 97331 USA La Trobe Univ, Dept Anim Plant & Soil Sci, Melbourne, Vic, Australia Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA Keele Univ, Fac Nat Sci, Keele ST5 5BG, Staffs, England %G English
Identifiers:ISSN:1061-4036 %R 10.1038/ng.3495 [ID No:1]
URL:<Go to ISI>://WOS:000370902600014 [ID No:2]
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