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          Institute: MPI für Entwicklungsbiologie     Collection: Abteilung 6 - Molecular Biology (D. Weigel)     Display Documents



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ID: 733131.0, MPI für Entwicklungsbiologie / Abteilung 6 - Molecular Biology (D. Weigel)
Epigenome confrontation triggers immediate reprogramming of DNA methylation and transposon silencing in Arabidopsis thaliana F1 epihybrids
Authors:Rigal, M.; Becker, C.; Pelissier, T.; Pogorelcnik, R.; Devos, J.; Ikeda, Y.; Weigel, D.; Mathieu, O.
Date of Publication (YYYY-MM-DD):2016-04-05
Title of Journal:Proc Natl Acad Sci u S A
Volume:113
Issue / Number:14
Start Page:E2083
End Page:92
Review Status:Internal review
Audience:Not Specified
Abstract / Description:Genes and transposons can exist in variable DNA methylation states, with potentially differential transcription. How these epialleles emerge is poorly understood. Here, we show that crossing an Arabidopsis thaliana plant with a hypomethylated genome and a normally methylated WT individual results, already in the F1 generation, in widespread changes in DNA methylation and transcription patterns. Novel nonparental and heritable epialleles arise at many genic loci, including a locus that itself controls DNA methylation patterns, but with most of the changes affecting pericentromeric transposons. Although a subset of transposons show immediate resilencing, a large number display decreased DNA methylation, which is associated with de novo or enhanced transcriptional activation and can translate into transposon mobilization in the progeny. Our findings reveal that the combination of distinct epigenomes can be viewed as an epigenomic shock, which is characterized by a round of epigenetic variation creating novel patterns of gene and TE regulation.
Free Keywords:Arabidopsis; DNA methylation; gene silencing; transcription; transposable elements
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Affiliations:MPI für Entwicklungsbiologie/Abteilung 6 - Molekulare Biologie (Detlef Weigel)
External Affiliations:Department of Molecular Biology, Max Planck Institute for Developmental Biology, D-72076 Tuebingen, Germany. Department of Molecular Biology, Max Planck Institute for Developmental Biology, D-72076 Tuebingen, Germany weigel@tue.mpg.de olivier.mathieu@univ-bpclermont.fr. Laboratoire Genetique Reproduction et Developpement, CNRS, UMR 6293, INSERM U1103, F-63001 Clermont-Ferrand, France; Laboratoire Genetique Reproduction et Developpement, Universite Clermont Auvergne, Universite Blaise Pascal, BP 10448, F-63000 Clermont-Ferrand, France; weigel@tue.mpg.de olivier.mathieu@univ-bpclermont.fr.
Identifiers:ISSN:1091-6490 (Electronic) 0027-8424 (Linking) %R 10.1... [ID No:1]
URL:http://www.ncbi.nlm.nih.gov/pubmed/27001853 [ID No:2]
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