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          Institute: MPI für Entwicklungsbiologie     Collection: Abteilungsunabhängige Arbeitsgruppen     Display Documents



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ID: 733163.0, MPI für Entwicklungsbiologie / Abteilungsunabhängige Arbeitsgruppen
Zebrafish Leucocyte tyrosine kinase controls iridophore establishment, proliferation and survival
Authors:Fadeev, A.; Krauss, J.; Singh, A. P.; Nusslein-Volhard, C.
Date of Publication (YYYY-MM-DD):2016-05
Title of Journal:Pigment Cell Melanoma Res
Volume:29
Issue / Number:3
Start Page:284
End Page:296
Review Status:Internal review
Audience:Not Specified
Abstract / Description:The zebrafish striped pattern results from the interplay among three pigment cell types; black melanophores, yellow xanthophores and silvery iridophores, making it a valuable model to study pattern formation in vivo. It has been suggested that iridophore proliferation, dispersal and cell shape transitions play an important role during stripe formation; however, the underlying molecular mechanisms remain poorly understood. Using gain- and loss-of-function alleles of leucocyte tyrosine kinase (ltk) and a pharmacological inhibitor approach, we show that Ltk specifically regulates iridophore establishment, proliferation and survival. Mutants in shady/ltk lack iridophores and display an abnormal body stripe pattern. Moonstone mutants, ltk(mne) , display ectopic iridophores, suggesting hyperactivity of the mutant Ltk. The dominant ltk(mne) allele carries a missense mutation in a conserved position of the kinase domain that highly correlates with neuroblastomas in mammals. Chimeric analysis suggests a novel physiological role of Ltk in the regulation of iridophore proliferation by homotypic competition.
Free Keywords:Aging; Amino Acid Sequence; Animals; Base Sequence; Behavior, Animal; Body Patterning; Cell Communication; Cell Proliferation; Cell Survival; Chromatophores/*cytology/*enzymology; Melanophores/cytology/metabolism; Mutation/genetics; Phenotype; Protein-Tyrosine Kinases/chemistry/genetics/*metabolism; Zebrafish/*metabolism; Zebrafish Proteins/chemistry/genetics/*metabolism; homotypic competition; iridophores; leucocyte tyrosine kinase; pigment cells; tumorigenesis; zebrafish
External Publication Status:published
Document Type:Article
Affiliations:MPI für Entwicklungsbiologie/Abteilungsunabhängige Arbeitsgruppen/Emeritus-Arbeitsgruppe C. Nüsslein-Volhard
Identifiers:ISSN:1755-148X (Electronic) 1755-1471 (Linking) %R 10.1... [ID No:1]
URL:https://www.ncbi.nlm.nih.gov/pubmed/26801003 [ID No:2]
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