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          Institute: MPI für molekulare Biomedizin     Collection: Jahrbuch 2018 (publ. 2017, arch)     Display Documents



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ID: 744087.0, MPI für molekulare Biomedizin / Jahrbuch 2018 (publ. 2017, arch)
Totipotency in the mouse
Authors:Wu, G.; Lei, L.; Scholer, H. R.
Date of Publication (YYYY-MM-DD):2017-07
Title of Journal:J Mol Med (Berl)
Volume:95
Issue / Number:7
Start Page:687
End Page:694
Review Status:Internal review
Audience:Not Specified
Abstract / Description:In mammals, the unicellular zygote starts the process of embryogenesis and differentiates into all types of somatic cells, including both fetal and extraembryonic lineages-in a highly organized manner to eventually give rise to an entire multicellular organism comprising more than 200 different tissue types. This feature is referred to as totipotency. Upon fertilization, oocyte maternal factors epigenetically reprogram the genomes of the terminally differentiated oocyte and spermatozoon and turn the zygote into a totipotent cell. Today, we still do not fully understand the molecular properties of totipotency. In this review, we discuss recent findings on the molecular signature and mechanism of transcriptional regulation networks in the totipotent mouse embryo.
Free Keywords:Animals; DNA Demethylation; Embryo, Mammalian/embryology/metabolism; Epigenesis, Genetic; *Gene Expression Regulation, Developmental; Gene Regulatory Networks; Histone Code; Mice/*embryology/*genetics; Octamer Transcription Factor-3/genetics; Transcriptional Activation; Zygote/cytology/metabolism; Totipotency; Transcription factors; Zygote
External Publication Status:published
Document Type:Article
Communicated by:MPI für molekulare Biomedizin
Affiliations:MPI für molekulare Biomedizin
External Affiliations:Department of Histology and Embryology, Harbin Medical University, 194 Xuefu Road, Nangang District, Harbin, 150081, China. Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Rontgenstrasse 20, 48149, Munster, Germany. office@mpi-muenster.mpg.de. Medical Faculty, University of Munster, Domagkstr. 3, 48149, Munster, Germany. office@mpi-muenster.mpg.de.
Identifiers:ISSN:1432-1440 (Electronic) 0946-2716 (Linking) %R 10.1... [ID No:1]
URL:https://www.ncbi.nlm.nih.gov/pubmed/28102431 [ID No:2]
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