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          Institute: MPI für molekulare Biomedizin     Collection: Jahrbuch 2018 (publ. 2017, arch)     Display Documents



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ID: 744106.0, MPI für molekulare Biomedizin / Jahrbuch 2018 (publ. 2017, arch)
Integrins are required for tissue organization and restriction of neurogenesis in regenerating planarians
Authors:Seebeck, F.; Marz, M.; Meyer, A. W.; Reuter, H.; Vogg, M. C.; Stehling, M.; Mildner, K.; Zeuschner, D.; Rabert, F.; Bartscherer, K.
Date of Publication (YYYY-MM-DD):2017-03-01
Title of Journal:Development
Volume:144
Issue / Number:5
Start Page:795
End Page:807
Review Status:Internal review
Audience:Not Specified
Abstract / Description:Tissue regeneration depends on proliferative cells and on cues that regulate cell division, differentiation, patterning and the restriction of these processes once regeneration is complete. In planarians, flatworms with high regenerative potential, muscle cells express some of these instructive cues. Here, we show that members of the integrin family of adhesion molecules are required for the integrity of regenerating tissues, including the musculature. Remarkably, in regenerating beta1-integrin RNAi planarians, we detected increased numbers of mitotic cells and progenitor cell types, as well as a reduced ability of stem cells and lineage-restricted progenitor cells to accumulate at wound sites. These animals also formed ectopic spheroid structures of neural identity in regenerating heads. Interestingly, those polarized assemblies comprised a variety of neural cells and underwent continuous growth. Our study indicates that integrin-mediated cell adhesion is required for the regenerative formation of organized tissues and for restricting neurogenesis during planarian regeneration.
Free Keywords:Animals; Body Patterning; Cell Adhesion; Cell Differentiation; Cell Proliferation; *Gene Expression Regulation, Developmental; In Situ Hybridization; Integrin beta1/*physiology; Neurogenesis/*physiology; Neurons/cytology; Phylogeny; Planarians/*physiology; RNA Interference; Regeneration/*physiology; Signal Transduction; Stem Cells/cytology; *Ectospheres; *Integrins; *Patterning; *Planaria; *Regeneration; *Stem cells
External Publication Status:published
Document Type:Article
Communicated by:MPI für molekulare Biomedizin
Affiliations:MPI für molekulare Biomedizin
External Affiliations:Medical Faculty, University of Munster, Albert-Schweitzer-Campus 1, 48149 Munster, Germany. Flow Cytometry Unit, Max Planck Institute for Molecular Biomedicine, Rontgenstrasse 20, Munster 48149, Germany. Electron Microscopy Unit, Max Planck Institute for Molecular Biomedicine, Rontgenstrasse 20, Munster 48149, Germany. Max Planck Research Group Stem Cells & Regeneration, Max Planck Institute for Molecular Biomedicine, Von-Esmarch-Str. 54, Munster 48149, Germany kerstin.bartscherer@mpi-muenster.mpg.de.
Identifiers:ISSN:1477-9129 (Electronic) 0950-1991 (Linking) %R 10.1... [ID No:1]
URL:https://www.ncbi.nlm.nih.gov/pubmed/28137894 [ID No:2]
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