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          Institute: MPI für molekulare Biomedizin     Collection: Jahrbuch 2018 (publ. 2017, arch)     Display Documents



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ID: 744119.0, MPI für molekulare Biomedizin / Jahrbuch 2018 (publ. 2017, arch)
Generic wound signals initiate regeneration in missing-tissue contexts
Authors:Owlarn, S.; Klenner, F.; Schmidt, D.; Rabert, F.; Tomasso, A.; Reuter, H.; Mulaw, M. A.; Moritz, S.; Gentile, L.; Weidinger, G.; Bartscherer, K.
Date of Publication (YYYY-MM-DD):2017-12-22
Title of Journal:Nat Commun
Volume:8
Issue / Number:1
Start Page:2282
Review Status:Internal review
Audience:Not Specified
Abstract / Description:Despite the identification of numerous regulators of regeneration in different animal models, a fundamental question remains: why do some wounds trigger the full regeneration of lost body parts, whereas others resolve by mere healing? By selectively inhibiting regeneration initiation, but not the formation of a wound epidermis, here we create headless planarians and finless zebrafish. Strikingly, in both missing-tissue contexts, injuries that normally do not trigger regeneration activate complete restoration of heads and fin rays. Our results demonstrate that generic wound signals have regeneration-inducing power. However, they are interpreted as regeneration triggers only in a permissive tissue context: when body parts are missing, or when tissue-resident polarity signals, such as Wnt activity in planarians, are modified. Hence, the ability to decode generic wound-induced signals as regeneration-initiating cues may be the crucial difference that distinguishes animals that regenerate from those that cannot.
Free Keywords:Animal Fins/physiology; Animals; Head/physiology; MAP Kinase Signaling System/*genetics; Planarians/*genetics/physiology; Regeneration/*genetics/physiology; Signal Transduction; Wnt Signaling Pathway/*genetics; Wound Healing/*genetics/physiology; Wounds and Injuries; Zebrafish/*genetics/physiology
External Publication Status:published
Document Type:Article
Communicated by:MPI für molekulare Biomedizin
Affiliations:MPI für molekulare Biomedizin
External Affiliations:Medical Faculty, University of Munster, Albert-Schweitzer-Campus 1, 48149, Munster, Germany. Institute of Biochemistry and Molecular Biology, Ulm University, Albert-Einstein-Allee 11, 89081, Ulm, Germany. Institute of Experimental Cancer Research, Ulm University, Albert-Einstein-Allee 11, 89081, Ulm, Germany. Pluripotency and Regeneration Group, Fraunhofer Institute for Biomedical Engineering, Ensheimerstr. 48, 66386, St. Ingbert, Germany. Institute of Biochemistry and Molecular Biology, Ulm University, Albert-Einstein-Allee 11, 89081, Ulm, Germany. gilbert.weidinger@uni-ulm.de. Max Planck Institute for Molecular Biomedicine, Von-Esmarch-Str. 54, 48149, Munster, Germany. kerstin.bartscherer@mpi-muenster.mpg.de. Medical Faculty, University of Munster, Albert-Schweitzer-Campus 1, 48149, Munster, Germany. kerstin.bartscherer@mpi-muenster.mpg.de.
Identifiers:ISSN:2041-1723 (Electronic) 2041-1723 (Linking) %R 10.1... [ID No:1]
URL:https://www.ncbi.nlm.nih.gov/pubmed/29273738 [ID No:2]
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