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          Institute: MPI für molekulare Biomedizin     Collection: Jahrbuch 2018 (publ. 2017, arch)     Display Documents



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ID: 744126.0, MPI für molekulare Biomedizin / Jahrbuch 2018 (publ. 2017, arch)
Generation and cardiac subtype-specific differentiation of PITX2-deficient human iPS cell lines for exploring familial atrial fibrillation
Authors:Marczenke, M.; Fell, J.; Piccini, I.; Ropke, A.; Seebohm, G.; Greber, B.
Date of Publication (YYYY-MM-DD):2017-05
Title of Journal:Stem Cell Res
Volume:21
Start Page:26
End Page:28
Review Status:Internal review
Audience:Not Specified
Abstract / Description:Loss-of-function mutations in the PITX2 transcription factor gene have been shown to cause familial atrial fibrillation (AF). To potentially model aspects of AF and unravel PITX2-regulated downstream genes for drug target discovery, we here report the generation of integration-free PITX2-deficient hiPS cell lines. We also show that both PITX2 knockout hiPS cells and isogenic wild-type controls can selectively be differentiated into human atrial cardiomyocytes, to potentially uncover differentially expressed gene sets between these groups.
External Publication Status:published
Document Type:Article
Communicated by:MPI für molekulare Biomedizin
Affiliations:MPI für molekulare Biomedizin
External Affiliations:Human Stem Cell Pluripotency Laboratory, Max Planck Institute for Molecular Biomedicine, Munster, Germany; Department of Cardiovascular Medicine, Institute of Genetics of Heart Diseases, University of Munster Medical School, Munster, Germany. Institute of Human Genetics, University Hospital Munster, Munster, Germany. Department of Cardiovascular Medicine, Institute of Genetics of Heart Diseases, University of Munster Medical School, Munster, Germany. Human Stem Cell Pluripotency Laboratory, Max Planck Institute for Molecular Biomedicine, Munster, Germany; Chemical Genomics Centre of the Max Planck Society, Dortmund, Germany. Electronic address: boris.greber@mpi-muenster.mpg.de.
Identifiers:ISSN:1876-7753 (Electronic) 1873-5061 (Linking) %R 10.1... [ID No:1]
URL:https://www.ncbi.nlm.nih.gov/pubmed/28677534 [ID No:2]
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