Home News About Us Contact Contributors Disclaimer Privacy Policy Help FAQ

Quick Search
My eDoc
Session History
Support Wiki
Direct access to
document ID:

          Institute: MPI für molekulare Biomedizin     Collection: Jahrbuch 2018 (publ. 2017, arch)     Display Documents

ID: 744131.0, MPI für molekulare Biomedizin / Jahrbuch 2018 (publ. 2017, arch)
Cell-matrix signals specify bone endothelial cells during developmental osteogenesis
Authors:Langen, U. H.; Pitulescu, M. E.; Kim, J. M.; Enriquez-Gasca, R.; Sivaraj, K. K.; Kusumbe, A. P.; Singh, A.; Di Russo, J.; Bixel, M. G.; Zhou, B.; Sorokin, L.; Vaquerizas, J. M.; Adams, R. H.
Date of Publication (YYYY-MM-DD):2017-03
Title of Journal:Nat Cell Biol
Issue / Number:3
Start Page:189
End Page:201
Review Status:Internal review
Audience:Not Specified
Abstract / Description:Blood vessels in the mammalian skeletal system control bone formation and support haematopoiesis by generating local niche environments. While a specialized capillary subtype, termed type H, has been recently shown to couple angiogenesis and osteogenesis in adolescent, adult and ageing mice, little is known about the formation of specific endothelial cell populations during early developmental endochondral bone formation. Here, we report that embryonic and early postnatal long bone contains a specialized endothelial cell subtype, termed type E, which strongly supports osteoblast lineage cells and later gives rise to other endothelial cell subpopulations. The differentiation and functional properties of bone endothelial cells require cell-matrix signalling interactions. Loss of endothelial integrin beta1 leads to endothelial cell differentiation defects and impaired postnatal bone growth, which is, in part, phenocopied by endothelial cell-specific laminin alpha5 mutants. Our work outlines fundamental principles of vessel formation and endothelial cell differentiation in the developing skeletal system.
Free Keywords:Adipokines/metabolism; Animals; Apelin; Bone and Bones/blood supply/*cytology/diagnostic imaging; Capillaries/cytology; Cell Adhesion; Endothelial Cells/*metabolism; Extracellular Matrix/*metabolism; Flow Cytometry; Immunohistochemistry; Integrases/metabolism; Integrin beta1/metabolism; Intercellular Signaling Peptides and Proteins/metabolism; Mice, Inbred C57BL; Mice, Mutant Strains; Neovascularization, Physiologic; *Osteogenesis; Phenotype; *Signal Transduction; X-Ray Microtomography
External Publication Status:published
Document Type:Article
Communicated by:MPI für molekulare Biomedizin
Affiliations:MPI für molekulare Biomedizin
External Affiliations:Max Planck Institute for Molecular Biomedicine, Research Group Regulatory Genomics, D-48149 Munster, Germany. Institute of Physiological Chemistry and Pathobiochemistry and Cells-in-Motion Cluster of Excellence, University of Munster, D-48149 Munster, Germany. Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Identifiers:ISSN:1476-4679 (Electronic) 1465-7392 (Linking) %R 10.1... [ID No:1]
URL:https://www.ncbi.nlm.nih.gov/pubmed/28218908 [ID No:2]
The scope and number of records on eDoc is subject to the collection policies defined by each institute - see "info" button in the collection browse view.