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          Institute: MPI für molekulare Biomedizin     Collection: Jahrbuch 2018 (publ. 2017, arch)     Display Documents



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ID: 744164.0, MPI für molekulare Biomedizin / Jahrbuch 2018 (publ. 2017, arch)
Molecular pathogenesis of peripheral neuropathies: insights from Drosophila models
Authors:Bussmann, J.; Storkebaum, E.
Date of Publication (YYYY-MM-DD):2017-06
Title of Journal:Curr Opin Genet Dev
Volume:44
Start Page:61
End Page:73
Review Status:Internal review
Audience:Not Specified
Abstract / Description:Peripheral neuropathies are characterized by degeneration of peripheral motor, sensory and/or autonomic axons, leading to progressive distal muscle weakness, sensory deficits and/or autonomic dysfunction. Acquired peripheral neuropathies, e.g., as a side effect of chemotherapy, are distinguished from inherited peripheral neuropathies (IPNs). Drosophila models for chemotherapy-induced peripheral neuropathy and several IPNs have provided novel insight into the molecular mechanisms underlying axonal degeneration. Forward genetic screens have predictive value for discovery of human IPN genes, and the pathogenicity of novel mutations in known IPN genes can be evaluated in Drosophila. Future screens for genes and compounds that modify Drosophila IPN phenotypes promise to make valuable contributions to unraveling the molecular pathogenesis and identification of therapeutic targets for these incurable diseases.
Free Keywords:Animals; Disease Models, Animal; Drosophila melanogaster/*genetics; Drug-Related Side Effects and Adverse Reactions/*genetics/physiopathology; Humans; Mutation; Peripheral Nervous System Diseases/chemically induced/*genetics/physiopathology
External Publication Status:published
Document Type:Article
Communicated by:MPI für molekulare Biomedizin
Affiliations:MPI für molekulare Biomedizin
External Affiliations:Molecular Neurogenetics Laboratory, Max Planck Institute for Molecular Biomedicine, 48149 Munster, Germany; Faculty of Medicine, University of Munster, 48149 Munster, Germany. Electronic address: erik.storkebaum@mpi-muenster.mpg.de.
Identifiers:ISSN:1879-0380 (Electronic) 0959-437X (Linking) %R 10.1... [ID No:1]
URL:https://www.ncbi.nlm.nih.gov/pubmed/28213160 [ID No:2]
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