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          Institute: MPI für Neurobiologie     Collection: Neuroimmunology     Display Documents



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ID: 9929.0, MPI für Neurobiologie / Neuroimmunology
Measles virus-specific T-cell immunity in rodent models
Authors:Weidinger, G.
Language:English
Date of Publication (YYYY-MM-DD):2002
Title of Journal:Viral Immunology
Journal Abbrev.:Viral Immunol.
Volume:15
Issue / Number:3
Start Page:429
End Page:434
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Measles virus (MV) infection still belongs to the most important infectious diseases world wide. To identify the components of the immune system that combat MV infection, infection models in rodents have been established. In rats and mice, the immune response to experimental MV infection is governed by the major histocombatibility complex (MHC). According to the MHC haplotype, the functional composition of the T-cell subsets determines the degree of susceptibility to experimental measles virus infection. CD4(+) T-cells are the most important T-cell subset in combating experimental MV infection in rodents. However, the mechanism of action still remains to be elucidated.
External Publication Status:published
Document Type:Article
Affiliations:MPI für Neurobiologie/Neuroimmunology (Wekerle)
Identifiers:ISI:000178294800005
ISSN:0882-8245
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