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Entries: 1-10  
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Post-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and release.
Authors: Hazra, S.; Szewczak, A.; Ort, S.; Konrad, M.; Lavie, A.
Date of Publication (YYYY-MM-DD): 2011-04-12
Title of Journal: Biochemistry
Volume: 50
Issue / Number: 14
Start Page: 2870
End Page: 2880
Document Type: Article
ID: 562642.0
The sugar ring of the nucleoside is required for productive substrate positioning in the active site of human deoxycytidine kinase (dCK): Implications for the development of dCK-activated acyclic guanine analogues.
Authors: Hazra, S.; Konrad, M.; Lavie, A.
Date of Publication (YYYY-MM-DD): 2010-07-14
Title of Journal: Journal of Medicinal Chemistry
Volume: 53
Issue / Number: 15
Start Page: 5792
End Page: 5800
Document Type: Article
ID: 493740.0
Structural and kinetic characterization of human deoxycytidine kinase variants able to phosphorylate 5-substituted deoxycytidine and thymidine analogues.
Authors: Hazra, S.; Ort, S.; Konrad, M.; Lavie, A.
Date of Publication (YYYY-MM-DD): 2010-07-08
Title of Journal: Biochemistry
Volume: 49
Issue / Number: 31
Start Page: 6784
End Page: 6790
Document Type: Article
ID: 493737.0
Extending thymidine kinase activity to the catalytic repertoire of human deoxycytidine kinase.
Authors: Hazra, S.; Sabini, E.; Ort, S.; Konrad, M.; Lavie, A.
Date of Publication (YYYY-MM-DD): 2009-02-17
Title of Journal: Biochemistry
Volume: 48
Issue / Number: 6
Start Page: 1256
End Page: 1263
Document Type: Article
ID: 420370.0
Restoration of the antiviral activity of 3'-azido-3'-deoxythymidine (AZT) against AZT-resistant human immunodeficiency virus by delivery of engineered thymidylate kinase to T cells.
Authors: Lavie, A.; Su, Y.; Ghassemi, M.; Novak, R. M.; Caffrey, M.; Sekulic, N.; Monnerjahn, C.; Konrad, M.; Cook, J. L.
Date of Publication (YYYY-MM-DD): 2008-07
Title of Journal: Journal of General Virology
Volume: 89
Issue / Number: 7
Start Page: 1672
End Page: 1679
Document Type: Article
ID: 377479.0
Design and intracellular delivery of enzymes to enhance metabolic activation of prodrugs and improve anticancer therapy.
Authors: Konrad, M.; McSorley, T.; Lavie, A.; Ort, S.
Date of Publication (YYYY-MM-DD): 2008-06-01
Title of Journal: FEBS Journal
Volume (in Journal): 275
Issue / Number: Suppl. 1
Start Page: 168
End Page: 168
Document Type: Conference-Paper
ID: 412619.0
Structural basis for substrate promiscuity of dCK.
Authors: Sabini, E.; Hazra, S.; Ort, S.; Konrad, M.; Lavie, A.
Date of Publication (YYYY-MM-DD): 2008-05-02
Title of Journal: Journal of Molecular Biology
Volume: 378
Issue / Number: 3
Start Page: 607
End Page: 621
Document Type: Article
ID: 360824.0
Mimicking phosphorylation of Ser-74 on human deoxycytidine kinase selectively increases catalytic activity for dC and dC analogues.
Authors: McSorley, T.; Ort, S.; Hazra, S.; Lavie, A.; Konrad, M.
Date of Publication (YYYY-MM-DD): 2008-03-05
Title of Journal: FEBS Letters
Volume: 582
Issue / Number: 5
Start Page: 720
End Page: 724
Document Type: Article
ID: 360821.0
Elucidation of different binding modes of purine nucleosides to human deoxycytidine kinase.
Authors: Sabini, E.; Hazra, S.; Konrad, M.; Lavie, A.
Date of Publication (YYYY-MM-DD): 2008
Title of Journal: Journal of Medicinal Chemistry
Volume: 51
Issue / Number: 14
Start Page: 4219
End Page: 4225
Document Type: Article
ID: 377487.0
Quaternary structure change as a mechanism for the regulation of thymidine kinase 1-like enzymes
Authors: Segura-Pena, D.; Lichter, J.; Trani, M.; Konrad, M.; Lavie, A.; Lutz, S.
Date of Publication (YYYY-MM-DD): 2007-12
Title of Journal: Structure
Volume: 15
Issue / Number: 12
Start Page: 1555
End Page: 1566
Document Type: Article
ID: 332894.0
Entries: 1-10  
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