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Entries: 1-10  
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Targeting Gain of Function and Resistance Mutations in Abl and KIT by Hybrid Compound Design
Authors: Richters, André; Ketzer, Julia; Getlik, Matthäus; Grütter, Christian; Schneider, Ralf; Heuckmann, Johannes M.; Heynck, Stefanie; Sos, Martin L.; Gupta, Anu; Unger, Anke; Schultz-Fademrecht, Carsten; Thomas, Roman K.; Bauer, Sebastian; Rauh, Daniel
Date of Publication (YYYY-MM-DD): 2013-07-25
Title of Journal: Journal of Medicinal Chemistry
Volume: 56
Issue / Number: 14
Start Page: 5757
End Page: 5772
Sequence Number of Article: 1
Document Type: Article
ID: 669113.0
Fluorophore Labeled Kinase Detects Ligands That Bind within the MAPK Insert of p38α Kinase
Authors: Getlik, Matthäus; Simard, Jeffrey R.; Termathe, Martin; Grütter, Christian; Rabiller, Matthias; Van Otterlo, Willem A. L.; Rauh, Daniel
Date of Publication (YYYY-MM-DD): 2012-07-02
Title of Journal: PLoS ONE
Volume: 7
Issue / Number: 7
Start Page: e39713-1
End Page: e39713-10
Sequence Number of Article: 1
Document Type: Article
ID: 611213.0
Direct Binding Assay for the Detection of Type IV Allosteric Inhibitors of Abl
Authors: Schneider, Ralf; Becker, Christian; Simard, Jefrrey R.; Getlik, Matthäus; Bohlke, Nina; Janning, Petra; Rauh, Daniel
Date of Publication (YYYY-MM-DD): 2012-06-06
Title of Journal: Journal of the American Chemical Society
Volume: 134
Issue / Number: 22
Start Page: 9138
End Page: 9141
Sequence Number of Article: 1
Document Type: Article
ID: 611010.0
Targeting GSK3 from Ustilago maydis: Type-II Kinase Inhibitors
as Potential Antifungals
Authors: Grütter, Christian; Simard, Jeffrey R.; Mayer-Wrangowski, Svenja C.; Schreier, Peter H.; Pérez-Martín, José; Richters, André; Getlik, Matthäus; Gutbrod, Oliver; Braun, Christoph A.; Beck, Michael E.; Rauh, Daniel
Date of Publication (YYYY-MM-DD): 2012-04-30
Title of Journal: ACS Chemical Biology
Volume: 7
Issue / Number: 7
Start Page: 1257
End Page: 1267
Sequence Number of Article: 1
Document Type: Article
ID: 614971.0
Strukturbasierte Entwicklung und Synthese von Enzyminhibitoren
Authors: Getlik, Matthäus
Name of University: Technische Universität Dortmund
Place of University: Dortmund
Date of Approval (YYYY-MM-DD): 2011-05
Document Type: PhD-Thesis
ID: 576386.0
Anticancer Properties of an Important Drug Lead Podophyllotoxin Can Be Efficiently Mimicked by Diverse Heterocyclic Scaffolds Accessible via One-Step Synthesis
Authors: Magedov, Igor V.; Frolova, Liliya; Manpadi, Madhuri; Bhoga, Uma devi; Tang, Hong; Evdokimov, Nikolai M.; George, Olivia; Georgiou, Kathy Hadje; Renner, Steffen; Getlik, Matthäus; Kinnibrugh, Tiffany L.; Fernandes, Manuel A.; Van Slambrouck, Severine; Steelant, Wim F. A.; Shuster, Charles B.; Rogelj, Snezna; Van Otterlo, Willem A. L.; Kornienko, Alexander
Date of Publication (YYYY-MM-DD): 2011
Title of Journal: Journal of Medicinal Chemistry
Volume: 54
Issue / Number: 12
Start Page: 4234
End Page: 4246
Sequence Number of Article: 1
Document Type: Article
ID: 570078.0
Fluorophore Labeling of the Glycine-Rich Loop as a Method of Identifying Inhibitors That Bind to Active and Inactive Kinase Conformations
Authors: Simard, Jeffrey R.; Getlik, Matthäus; Grütter, Christian; Schneider, Ralf; Wulfert, Sabine; Rauh, Daniel
Date of Publication (YYYY-MM-DD): 2010-04-03
Title of Journal: Journal of the American Chemical Society
Volume: 132
Issue / Number: 12
Start Page: 4152
End Page: 4160
Sequence Number of Article: 1
Document Type: Article
ID: 475002.0
Displacement Assay for the Detection of Stabilizers of Inactive Kinase Conformations
Authors: Klüter, Sabine; Grütter, Christian; Naqvi, Tabassum; Rabiller, Matthias; Simard, Jeffrey R.; Pawar, Vijaykumar; Getlik, Matthäus; Rauh, Daniel
Date of Publication (YYYY-MM-DD): 2010-01-14
Title of Journal: Journal of Medicinal Chemistry
Volume: 53
Issue / Number: 1
Start Page: 357
End Page: 367
Sequence Number of Article: 1
Document Type: Article
ID: 443578.0
Chemogenomic profiling provides insights into the limited activity of irreversible EGFR inhibitors in tumor cells expressing the T790M EGFR resistance mutation
Authors: Sos, Martin L.; Rode, Haridas B.; Heynck, Stefanie; Peifer, Martin; Fischer, Florian; Klüter, Sabine; Pawar, Vijakumar G.; Reuter, Cecile; Heuckmann, Johannes M.; Weiss, Jonathan; Ruddigkeit, Lars; Rabiller, Matthias; Koker, Mirjam; Simard, Jeffrey R.; Getlik, Matthäus; Yuza, Yuki; Chen, Tzu-Hsiu; Greulich, Heidi; Thomas, Roman K.; Rauh, Daniel
Date of Publication (YYYY-MM-DD): 2010
Title of Journal: Cancer Research
Volume: 70
Issue / Number: 3
Start Page: 868
End Page: 874
Document Type: Article
ID: 472769.0
Proteus in the World of Proteins: Conformational Changes in Protein Kinases
Authors: Rabiller, Matthias; Getlik, Matthäus; Klüter, Sabine; Richters, André; Tückmantel, Sandra; Simard, Jeffrey R.; Rauh, Daniel
Date of Publication (YYYY-MM-DD): 2010
Title of Journal: Archiv der Pharmazie
Volume: 343
Issue / Number: 4
Start Page: 193
End Page: 206
Sequence Number of Article: 1
Document Type: Article
ID: 476390.0
Entries: 1-10  
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