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Post-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and release.
Authors: Hazra, S.; Szewczak, A.; Ort, S.; Konrad, M.; Lavie, A.
Date of Publication (YYYY-MM-DD): 2011-04-12
Title of Journal: Biochemistry
Volume: 50
Issue / Number: 14
Start Page: 2870
End Page: 2880
Document Type: Article
ID: 562642.0
Structural and kinetic characterization of human deoxycytidine kinase variants able to phosphorylate 5-substituted deoxycytidine and thymidine analogues.
Authors: Hazra, S.; Ort, S.; Konrad, M.; Lavie, A.
Date of Publication (YYYY-MM-DD): 2010-07-08
Title of Journal: Biochemistry
Volume: 49
Issue / Number: 31
Start Page: 6784
End Page: 6790
Document Type: Article
ID: 493737.0
Extending thymidine kinase activity to the catalytic repertoire of human deoxycytidine kinase.
Authors: Hazra, S.; Sabini, E.; Ort, S.; Konrad, M.; Lavie, A.
Date of Publication (YYYY-MM-DD): 2009-02-17
Title of Journal: Biochemistry
Volume: 48
Issue / Number: 6
Start Page: 1256
End Page: 1263
Document Type: Article
ID: 420370.0
Design and intracellular delivery of enzymes to enhance metabolic activation of prodrugs and improve anticancer therapy.
Authors: Konrad, M.; McSorley, T.; Lavie, A.; Ort, S.
Date of Publication (YYYY-MM-DD): 2008-06-01
Title of Journal: FEBS Journal
Volume (in Journal): 275
Issue / Number: Suppl. 1
Start Page: 168
End Page: 168
Document Type: Conference-Paper
ID: 412619.0
Structural basis for substrate promiscuity of dCK.
Authors: Sabini, E.; Hazra, S.; Ort, S.; Konrad, M.; Lavie, A.
Date of Publication (YYYY-MM-DD): 2008-05-02
Title of Journal: Journal of Molecular Biology
Volume: 378
Issue / Number: 3
Start Page: 607
End Page: 621
Document Type: Article
ID: 360824.0
Mimicking phosphorylation of Ser-74 on human deoxycytidine kinase selectively increases catalytic activity for dC and dC analogues.
Authors: McSorley, T.; Ort, S.; Hazra, S.; Lavie, A.; Konrad, M.
Date of Publication (YYYY-MM-DD): 2008-03-05
Title of Journal: FEBS Letters
Volume: 582
Issue / Number: 5
Start Page: 720
End Page: 724
Document Type: Article
ID: 360821.0
Elucidation of the active conformation of the APS-kinase domain of human PAPS synthetase 1
Authors: Sekulic, N.; Dietrich, K.; Paarmann, I.; Ort, S.; Konrad, M.; Lavie, A.
Date of Publication (YYYY-MM-DD): 2007-03-23
Title of Journal: Journal of Molecular Biology
Volume: 367
Issue / Number: 2
Start Page: 488
End Page: 500
Document Type: Article
ID: 314846.0
Engineering of nucleoside kinases to improve the activation of nucleoside analog prodrugs
Authors: Konrad, M.; Ort, S.; Monnerjahn, C.; Lavie, A.
Date of Publication (YYYY-MM-DD): 2006-06
Title of Journal: FEBS Journal
Volume (in Journal): 273
Issue / Number: Suppl. 1
Start Page: 50
End Page: 50
Document Type: Conference-Paper
ID: 297558.0
Structural basis for the preference of UTP over ATP in human deoxycytidine kinase: Illuminating the role of main-chain reorganization.
Authors: Godsey, M. H.; Ort, S.; Sabini, E.; Konrad, M.; Lavie, A.
Date of Publication (YYYY-MM-DD): 2006-01-17
Title of Journal: Biochemistry
Volume: 45
Issue / Number: 2
Start Page: 452
End Page: 461
Document Type: Article
ID: 288358.0
Proteindesign zur Verbesserung des Nukleosidanaloga-Umsatzes in menschlichen Zellen: Desoxycytidin-Kinase und UMP/CMP-Kinase
Authors: Ort, S.
Name of University: Universität Göttingen
Place of University: Göttingen
Date of Approval (YYYY-MM-DD): 2005
Document Type: PhD-Thesis
ID: 434427.0
Entries: 1-10  
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