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Anticancer Properties of an Important Drug Lead Podophyllotoxin Can Be Efficiently Mimicked by Diverse Heterocyclic Scaffolds Accessible via One-Step Synthesis |
Authors: Magedov, Igor V.; Frolova, Liliya; Manpadi, Madhuri; Bhoga, Uma devi; Tang, Hong; Evdokimov, Nikolai M.; George, Olivia; Georgiou, Kathy Hadje; Renner, Steffen; Getlik, Matthäus; Kinnibrugh, Tiffany L.; Fernandes, Manuel A.; Van Slambrouck, Severine; Steelant, Wim F. A.; Shuster, Charles B.; Rogelj, Snezna; Van Otterlo, Willem A. L.; Kornienko, Alexander | Date of Publication (YYYY-MM-DD): 2011 | Title of Journal: Journal of Medicinal Chemistry | Volume: 54 | Issue / Number: 12 | Start Page: 4234 | End Page: 4246 | Sequence Number of Article: 1 | Document Type: Article | ID: 570078.0 |
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Characterization of Irreversible Kinase Inhibitors by Directly Detecting Covalent Bond Formation: A Tool for Dissecting Kinase Drug Resistance |
Authors: Klüter, Sabine; Simard, Jeffrey R.; Rode, Haridas B.; Grütter, Christian; Pawar, Vijaykumar; Raaijmakers, Hans C A.; Barf, Tjeerd A.; Rabiller, Matthias; van Otterlo, Willem A. L.; Rauh, Daniel | Date of Publication (YYYY-MM-DD): 2010-12-10 | Title of Journal: ChemBioChem | Volume: 11 | Issue / Number: 18 | Start Page: 2557 | End Page: 2566 | Sequence Number of Article: 1 | Document Type: Article | ID: 525509.0 |
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Bioactivity-guided mapping and navigation of chemical space |
Authors: Renner, Steffen; Van Otterlo, Willem A. L.; Dominguez Seoane, Marta; Möcklinghoff, Sabine; Hofmann, Bettina; Wetzel, Stefan; Schuffenhauer, Ansgar; Ertl, Peter; Oprea, Tudor I.; Steinhilber, Dieter; Brunsveld, Luc; Rauh, Daniel; Waldmann, Herbert | Date of Publication (YYYY-MM-DD): 2009-06-28 | Title of Journal: Nature Chemical Biology | Volume: 5 | Issue / Number: 8 | Start Page: 585 | End Page: 592 | Sequence Number of Article: 1 | Document Type: Article | ID: 433910.0 |
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