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Identification and characterization of novel classes of macrophage migration inhibitory factor (MIF) inhibitors with distinct mechanisms of action.
Authors: Ouertatani-Sakouhi, H.; El-Turk, F.; Fauvet, B.; Cho, M. K.; Karpinar, D. P.; Le Roy, D.; Dewor, M.; Roger, T.; Bernhagen, J.; Calandra, T.; Zweckstetter, M.; Lashuel, H. A.
Date of Publication (YYYY-MM-DD): 2010-08-20
Title of Journal: Journal of Biological Chemistry
Volume: 285
Issue / Number: 34
Start Page: 26581
End Page: 26598
Document Type: Article
ID: 533789.0


Entacapone and tolcapone, two catechol-O-methyltransferase inhibitors (ICOMT), block fibril formation of {alpha}-synuclein and {beta}-amyloid and protect against amyloid-induced toxicity.
Authors: Di Giovanni, S.; Eleuteri, S.; Paleologou, K. E.; Yin, G.; Zweckstetter, M.; Carrupt, P. A.; Lashuel, H. A.
Date of Publication (YYYY-MM-DD): 2010-05-14
Title of Journal: Journal of Biological Chemistry
Volume: 285
Start Page: 14941
End Page: 14954
Document Type: Article
ID: 450500.0


Phosphorylation at S87 is enhanced in synucleinopathies, inhibits α-synuclein oligomerization and influences synuclein-membrane interactions.
Authors: Paleologou, K. E.; Oueslati, A.; Shakked, G.; Rospigliosi, C. C.; Kim, H. Y.; Lamberto, G. R.; Fernandez, C. O.; Schmid, A.; Chegini, F.; Gai, W. P.; Chiappe, D.; Moniatte, M.; Schneider, B. L.; Aebischer, P.; Eliezer, D.; Zweckstetter, M.; Masliah, E.; Lashuel, H. A.
Date of Publication (YYYY-MM-DD): 2010-03-03
Title of Journal: The Journal of Neuroscience
Volume: 30
Issue / Number: 9
Start Page: 3184
End Page: 3198
Document Type: Article
ID: 450494.0


Phosphorylation of synucleins by members of the polo-like kinase family.
Authors: Mbefo, M. K.; Paleologou, K. E.; Boucharaba, A.; Oueslati, A.; Schell, H.; Fournier, M.; Olschewski, D.; Yin, G.; Zweckstetter, M.; Masliah, E.; Kahle, P. J.; Hirling, H.; Lashuel, H. A.
Date of Publication (YYYY-MM-DD): 2010-01-22
Title of Journal: The Journal of Biological Chemistry
Volume: 285
Issue / Number: 4
Start Page: 2807
End Page: 2822
Document Type: Article
ID: 442751.0


Structural properties of pore-forming oligomers of α-synuclein.
Authors: Kim, H. Y.; Cho, M. K.; Kumar, A.; Maier, E.; Siebenhaar, C.; Becker, S.; Fernandez, C. O.; Lashuel, H. A.; Benz, R.; Lange, A.; Zweckstetter, M.
Date of Publication (YYYY-MM-DD): 2009-11-04
Title of Journal: Journal of the American Chemical Society
Volume: 131
Issue / Number: 47
Start Page: 17482
End Page: 17489
Document Type: Article
ID: 442646.0


A new class of isothiocyanate-based irreversible inhibitors of macrophage migration inhibitory factor.
Authors: Ouertatani-Sakouhi, H.; El-Turk, F.; Fauvet, B.; Roger, T.; Le Roy, D.; Karpinar, P.; Leng, L.; Bucala, R.; Zweckstetter, M.; Calandra, T.; Lashuel, H. A.
Date of Publication (YYYY-MM-DD): 2009-09-08
Title of Journal: Biochemistry
Volume: 48
Issue / Number: 41
Start Page: 9858
End Page: 9870
Document Type: Article
ID: 442652.0


The conformational flexibility of the carboxy terminal residues 105−114 Is a key modulator of the catalytic activity and stability of macrophage migration inhibitory factor.
Authors: El-Turk, F.; Cascella, M.; Ouertatami-Sakonhi, H.; Lakshmi, R. N.; Leng, L.; Bucala, R.; Zweckstetter, M.; Rothlisberger, U.; Lashuel, H. A.
Date of Publication (YYYY-MM-DD): 2008-10-07
Title of Journal: Biochemistry
Volume: 47
Issue / Number: 40
Start Page: 10740
End Page: 10756
Document Type: Article
ID: 411661.0


Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of α-synuclein.
Authors: Paleologou, K. E.; Schmid, A. W.; Rospigliosi, C. C.; Kim, H. Y.; Lamberto, G. R.; Fredenburg, R. A.; Lansbury, P. T.; Fernandez, C. O.; Eliezer, D.; Zweckstetter, M.; Lashuel, H. A.
Date of Publication (YYYY-MM-DD): 2008-06
Title of Journal: The Journal of Biological Chemistry
Volume: 283
Start Page: 16895
End Page: 16905
Document Type: Article
ID: 377539.0