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Natural-product-derived fragments for fragment-based ligand discovery
Authors: Over, Björn; Wetzel, Stefan; Grütter, Christian; Nakai, Yasushi; Renner, Steffen; Rauh, Daniel; Waldmann, Herbert
Date of Publication (YYYY-MM-DD): 2013-01
Title of Journal: Nature Chemistry
Volume: 5
Issue / Number: 1
Start Page: 21
End Page: 28
Sequence Number of Article: 1
Document Type: Article
ID: 628939.0


Development of Highly Potent Inhibitors of the Ras-Targeting Human Acyl Protein Thioesterases Based on Substrate Similarity Design
Authors: Hedberg, Christian; Dekker, Frank J.; Rusch, Marion; Renner, Steffen; Wetzel, Stefan; Vartak, Nachiket; Gerding-Reimers, Claas; Bon, Robin S.; Bastiaens, Philippe I. H.; Waldmann, Herbert
Date of Publication (YYYY-MM-DD): 2011-10-10
Title of Journal: Angewandte Chemie
Volume: 123
Issue / Number: 42
Start Page: 10006
End Page: 10011
Sequence Number of Article: 1
Document Type: Article
ID: 574000.0


Development of Highly Potent Inhibitors of the Ras-Targeting Human Acyl Protein Thioesterases Based on Substrate Similarity Design
Authors: Hedberg, Christian; Dekker, Frank J.; Rusch, Marion; Renner, Steffen; Wetzel, Stefan; Vartak, Nachiket; Gerding-Reimers, Claas; Bon, Robin S.; Bastiaens, Philippe I. H.; Waldmann, Herbert
Date of Publication (YYYY-MM-DD): 2011-10-10
Title of Journal: Angewandte Chemie International Edition
Volume: 50
Issue / Number: 42
Start Page: 9832
End Page: 9837
Sequence Number of Article: 1
Document Type: Article
ID: 574004.0


Anticancer Properties of an Important Drug Lead Podophyllotoxin Can Be Efficiently Mimicked by Diverse Heterocyclic Scaffolds Accessible via One-Step Synthesis
Authors: Magedov, Igor V.; Frolova, Liliya; Manpadi, Madhuri; Bhoga, Uma devi; Tang, Hong; Evdokimov, Nikolai M.; George, Olivia; Georgiou, Kathy Hadje; Renner, Steffen; Getlik, Matthäus; Kinnibrugh, Tiffany L.; Fernandes, Manuel A.; Van Slambrouck, Severine; Steelant, Wim F. A.; Shuster, Charles B.; Rogelj, Snezna; Van Otterlo, Willem A. L.; Kornienko, Alexander
Date of Publication (YYYY-MM-DD): 2011
Title of Journal: Journal of Medicinal Chemistry
Volume: 54
Issue / Number: 12
Start Page: 4234
End Page: 4246
Sequence Number of Article: 1
Document Type: Article
ID: 570078.0


Small-molecule inhibition of APT1 affects Ras localization and signaling
Authors: Dekker, Frank J.; Rocks, Oliver; Vartak, Nachiket; Menninger, Sascha; Hedberg, Christian; Balamurugan, Rangarajan; Wetzel, Stefan; Renner, Steffen; Gerauer, Marc; Schölermann, Beate; Rusch, Marion; Kramer, John W.; Rauh, Daniel; Coates, Geoffrey W.; Brunsveld, Luc; Bastiaens, Philippe I. H.; Waldmann, Herbert
Date of Publication (YYYY-MM-DD): 2010-04
Title of Journal: Nature Chemical Biology
Volume: 6
Issue / Number: 6
Start Page: 449
End Page: 456
Sequence Number of Article: 1
Document Type: Article
ID: 476024.0


A Scaffold-Tree-Merging Strategy for Prospective Bioactivity Annotation of γ-Pyrones
Authors: Wetzel, Stefan; Wilk, Wolfram; Chammaa, Samy; Sperl, Bianca; Roth, Anke G.; Yektaoglu, Aybike; Renner, Steffen; Berg, Thorsten; Arenz, Christoph; Giannis, Athanassios; Oprea, Tudor I.; Rauh, Daniel; Kaiser, Markus; Waldmann, Herbert
Date of Publication (YYYY-MM-DD): 2010
Title of Journal: Angewandte Chemie International Edition
Volume: 49
Issue / Number: 21
Start Page: 3666
End Page: 3670
Sequence Number of Article: 1
Document Type: Article
ID: 476752.0


Interactive Exploration of Chemical Space with Scaffold Hunter
Authors: Wetzel, Stefan; Klein, Karsten; Renner, Steffen; Rauh, Daniel; Oprea, Tudor I.; Mutzel, Petra; Waldmann, Herbert
Date of Publication (YYYY-MM-DD): 2009-06-28
Title of Journal: Nature Chemical Biology
Volume: 5
Issue / Number: 8
Start Page: 581
End Page: 583; 696
Sequence Number of Article: 1
Document Type: Article
ID: 429252.0


Bioactivity-guided mapping and navigation of chemical space
Authors: Renner, Steffen; Van Otterlo, Willem A. L.; Dominguez Seoane, Marta; Möcklinghoff, Sabine; Hofmann, Bettina; Wetzel, Stefan; Schuffenhauer, Ansgar; Ertl, Peter; Oprea, Tudor I.; Steinhilber, Dieter; Brunsveld, Luc; Rauh, Daniel; Waldmann, Herbert
Date of Publication (YYYY-MM-DD): 2009-06-28
Title of Journal: Nature Chemical Biology
Volume: 5
Issue / Number: 8
Start Page: 585
End Page: 592
Sequence Number of Article: 1
Document Type: Article
ID: 433910.0


Synthesis and Structure-Activity Correlation of a Brunsvicamide-Inspired Cyclopeptide Collection
Authors: Walther, Thilo; Renner, Steffen; Waldmann, Herbert; Arndt, Hans-Dieter
Date of Publication (YYYY-MM-DD): 2009-04-09
Title of Journal: ChemBioChem
Volume: 10
Issue / Number: 7
Start Page: 1153
End Page: 1162
Sequence Number of Article: 1
Document Type: Article
ID: 431631.0


Totalsynthese von Chondramid C und Bindung an F-Aktin
Authors: Waldmann, Herbert; Hu, Tai-Shan; Renner, Steffen; Menninger, Sascha; Tannert, René; Oda, Toshiro; Arndt, Hans-Dieter
Date of Publication (YYYY-MM-DD): 2008-07-15
Title of Journal: Angewandte Chemie
Volume: 120
Issue / Number: 34
Start Page: 6573
End Page: 6577
Sequence Number of Article: 1
Document Type: Article
ID: 371922.0