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Overcoming Compound Fluorescence in the FLiK Screening Assay with Red-Shifted Fluorophores
Authors: Schneider, Ralf; Gohla, Anne; Simard, Jeffrey R.; Yadav, Dharmendra B.; Fang, Zhizhou; Van Otterlo, Willem A. L.; Rauh, Daniel
Date of Publication (YYYY-MM-DD): 2013-06-05
Title of Journal: Journal of the American Chemical Society
Volume: 135
Issue / Number: 22
Start Page: 8400
End Page: 8408
Sequence Number of Article: 1
Document Type: Article
ID: 668198.0


Selective Detection of Allosteric Phosphatase Inhibitors
Authors: Schneider, Ralf; Beumer, Claudia; Simard, Jeffrey R.; Grütter, Christian; Rauh, Daniel
Date of Publication (YYYY-MM-DD): 2013-05-08
Title of Journal: Journal of the American Chemical Society
Volume: 135
Issue / Number: 18
Start Page: 6838
End Page: 6841
Sequence Number of Article: 1
Document Type: Article
ID: 667307.0


Fluorophore Labeled Kinase Detects Ligands That Bind within the MAPK Insert of p38α Kinase
Authors: Getlik, Matthäus; Simard, Jeffrey R.; Termathe, Martin; Grütter, Christian; Rabiller, Matthias; Van Otterlo, Willem A. L.; Rauh, Daniel
Date of Publication (YYYY-MM-DD): 2012-07-02
Title of Journal: PLoS ONE
Volume: 7
Issue / Number: 7
Start Page: e39713-1
End Page: e39713-10
Sequence Number of Article: 1
Document Type: Article
ID: 611213.0


Targeting GSK3 from Ustilago maydis: Type-II Kinase Inhibitors
as Potential Antifungals
Authors: Grütter, Christian; Simard, Jeffrey R.; Mayer-Wrangowski, Svenja C.; Schreier, Peter H.; Pérez-Martín, José; Richters, André; Getlik, Matthäus; Gutbrod, Oliver; Braun, Christoph A.; Beck, Michael E.; Rauh, Daniel
Date of Publication (YYYY-MM-DD): 2012-04-30
Title of Journal: ACS Chemical Biology
Volume: 7
Issue / Number: 7
Start Page: 1257
End Page: 1267
Sequence Number of Article: 1
Document Type: Article
ID: 614971.0


Identification of Ustilago maydis Aurora Kinase As a Novel Antifungal Target
Authors: Tückmantel, Sandra; Greul, Jörg N.; Janning, Petra; Brockmeyer, Andreas; Grütter, Christian; Simard, Jeffrey R.; Gutbrod, Oliver; Beck, Michael E.; Tietjen, Klaus; Rauh, Daniel; Schreier, Peter H.
Date of Publication (YYYY-MM-DD): 2011-09
Title of Journal: Asc Chemical Biology
Volume: 6
Issue / Number: 9
Start Page: 926
End Page: 933
Sequence Number of Article: 1
Document Type: Article
ID: 572728.0


Synthesis and biological evaluation of 7-substituted-1-(3-bromophenylamino)isoquinoline-4-carbonitriles
as inhibitors of myosin light chain kinase and epidermal
growth factor receptor
Authors: Rode, Haridas B.; Sos, Martin L.; Grütter, Christian; Heynck, Stefanie; Simard, Jeffrey R.; Rauh, Daniel
Date of Publication (YYYY-MM-DD): 2011-01
Title of Journal: Bioorganic & Medicinal Chemistry
Volume: 19
Issue / Number: 1
Start Page: 429
End Page: 439
Sequence Number of Article: 1
Document Type: Article
ID: 535425.0


Synthesis and biological evaluation of 7-substituted-1-(3-bromophenylamino)isoquinoline-4-carbonitriles as inhibitors of myosin light chain kinase and epidermal growth factor receptor
Authors: Rode, Harras B.; Sos, Martin L.; Grütter, Christian; Heynck, Stefanie; Simard, Jeffrey R.; Rauh, Daniel
Date of Publication (YYYY-MM-DD): 2011
Title of Journal: Bioorganic and Medicinal Chemistry
Volume: 19
Issue / Number: 1
Start Page: 429
End Page: 439
Document Type: Article
ID: 522174.0


Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer
Authors: Hammerman, Peter S.; Sos, Martin L.; Ramos, Alex H.; Xu, Chunxiao; Dutt, Amit; Zhou, Wenjun; Brace, Lear E.; Woods, Brittany A.; Lin, Wenchu; Zhang, Jianming; Deng, Xianming; Lim, San Ming; Heynck, Stefanie; Peifer, Martin; Simard, Jeffrey R.; Lawrence, Michael S.; Onofrio, Robert C.; Salvesen, Helga B.; Seidel, Danila; Zander, Thomas; Heuckmann, Johannes M.; Soltermann, Alex; Moch, Holger; Koker, Mirjam; Leenders, Frauke; Gabler, Franziska; Querings, Silvia; Ansen, Sascha; Brambilla, Elisabeth; Brambilla, Christian; Lorimier, Philippe; Brustugun, Odd Terje; Helland, Aslaug; Petersen, Iver; Clement, Joachim H.; Groen, Harry; Timens, Wim; Sietsma, Hannie; Stoelben, Erich; Wolf, Jürgen; Beer, David G.; Tsao, Ming Sound; Hanna, Megan; Hatton, Charles; Eck, Michael J.; Janne, Pasi A.; Johnson, Bruce E.; Winckler, Wendy; Greulich, Heidi; Bass, Adam J.; Cho, Jeonghee; Rauh, Daniel; Gray, Nathanael S.; Wong, Kwok-Kin; Haura, Eric B.; Thomas, Roman K.; Meyerson, Matthew
Date of Publication (YYYY-MM-DD): 2011
Title of Journal: Cancer Discovery
Volume: 1
Issue / Number: 1
Start Page: 78
End Page: 89
Document Type: Article
ID: 589439.0


Characterization of Irreversible Kinase Inhibitors by Directly Detecting Covalent Bond Formation: A Tool for Dissecting Kinase Drug Resistance
Authors: Klüter, Sabine; Simard, Jeffrey R.; Rode, Haridas B.; Grütter, Christian; Pawar, Vijaykumar; Raaijmakers, Hans C A.; Barf, Tjeerd A.; Rabiller, Matthias; van Otterlo, Willem A. L.; Rauh, Daniel
Date of Publication (YYYY-MM-DD): 2010-12-10
Title of Journal: ChemBioChem
Volume: 11
Issue / Number: 18
Start Page: 2557
End Page: 2566
Sequence Number of Article: 1
Document Type: Article
ID: 525509.0


Fluorophore Labeling of the Glycine-Rich Loop as a Method of Identifying Inhibitors That Bind to Active and Inactive Kinase Conformations
Authors: Simard, Jeffrey R.; Getlik, Matthäus; Grütter, Christian; Schneider, Ralf; Wulfert, Sabine; Rauh, Daniel
Date of Publication (YYYY-MM-DD): 2010-04-03
Title of Journal: Journal of the American Chemical Society
Volume: 132
Issue / Number: 12
Start Page: 4152
End Page: 4160
Sequence Number of Article: 1
Document Type: Article
ID: 475002.0