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          Document History for Document ID 15668

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Document Version Version Comment Date Status
15668.0 [No comment] 16.10.2006 13:22 Released

ID: 15668.0, MPI für molekulare Zellbiologie und Genetik / Publikationen mpi-cbg 2003
SAS-4 is a C-elegans centriolar protein that controls centrosome size
Authors:Kirkham, M.; Müller-Reichert, T.; Oegema, K.; Grill, S.; Hyman, A. A.
Language:English
Date of Publication (YYYY-MM-DD):2003-02-21
Title of Journal:Cell
Journal Abbrev.:Cell
Volume:112
Issue / Number:4
Start Page:575
End Page:587
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Centrosomes consist of a centriole pair surrounded by pericentriolar material (PCM). Previous work suggested that centrioles are required to organize PCM to form a structurally stable organelle. Here, we characterize SAS-4, a centriole component in Caenorhabditis elegans. Like tubulin, SAS-4 is incorporated into centrioles during their duplication and remains stably associated thereafter. In the absence of SAS-4, centriole duplication falls. Partial depletion of SAS-4 results in structurally defective centrioles that contain reduced levels of SAS-4 and organize proportionally less PCM. Thus, SAS-4 is a centriole-associated component whose amount dictates centrosome size. These results provide novel insight into the poorly understood role of centrioles as centrosomal organizers.
Comment of the Author/Creator:Date: 2003, FEB 21
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für molekulare Zellbiologie und Genetik
External Affiliations:CMM-E 3080,9500 Gilman Dr, La Jolla, CA 92093 USA; Max Planck Inst Mol Cell Biol & Genet, D-01307 Dresden, Germany
Identifiers:ISI:000181252600014 [ID No:1]
ISSN:0092-8674 [ID No:2]