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251100.0 [No comment] 09.11.2011 10:47 Released

ID: 251100.0, MPI für evolutionäre Anthropologie / Publications MPI for Evolutionary Anthropology
Loss of Olfactory Receptor Genes Coincides with the Acquisition of Full Trichromatic Vision in Primates
Authors:Gilad, Yoav; Wiebe, Victor; Przeworski, Molly; Lancet, Doron; Pääbo, Svante
Date of Publication (YYYY-MM-DD):2004
Title of Journal:PLoS Biology
Issue / Number:1
Start Page:0120
End Page:0125
Copyright:© 2004 Gilad et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Olfactory receptor (OR) genes constitute the molecular basis for the sense of smell and are encoded by the largest gene family in mammalian genomes. Previous studies suggested that the proportion of pseudogenes in the OR gene family is significantly larger in humans than in other apes and significantly larger in apes than in the mouse. To investigate the process of degeneration of the olfactory repertoire in primates, we estimated the proportion of OR pseudogenes in 19 primate species by surveying randomly chosen subsets of 100 OR genes from each species. We find that apes, Old World monkeys and one New World monkey, the howler monkey, have a significantly higher proportion of OR pseudogenes than do other New World monkeys or the lemur (a prosimian). Strikingly, the howler monkey is also the only New World monkey to possess full trichromatic vision, along with Old World monkeys and apes. Our findings suggest that the deterioration of the olfactory repertoire occurred concomitant with the acquisition of full trichromatic color vision in primates.
External Publication Status:published
Document Type:Article
Communicated by:Gisela Lausberg
Affiliations:MPI für evolutionäre Anthropologie/Department of Evolutionary Genetics
External Affiliations:Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
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