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          Document History for Document ID 456805

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Document Version Version Comment Date Status
456805.0 [No comment] 24.02.2010 14:58 Released

ID: 456805.0, MPI für molekulare Genetik / Ribosome Research Groups
An unexpected type of ribosomes induced by kasugamycin : a look into ancestral times of protein synthesis?
Authors:Kaberdina, Anna Chao; Szaflarski, Witold; Nierhaus, Knud H.; Moll, Isabella
Language:English
Date of Publication (YYYY-MM-DD):2009-01-30
Title of Journal:Molecular Cell
Journal Abbrev.:Mol Cell
Volume:33
Issue / Number:2
Start Page:227
End Page:236
Copyright:© 2009 Elsevier B.V.
Review Status:not specified
Audience:Experts Only
Abstract / Description:Translation of leaderless mRNAs, lacking ribosomal recruitment signals other than the 5′-terminal AUG-initiating codon, occurs in all three domains of life. Contemporary leaderless mRNAs may therefore be viewed as molecular fossils resembling ancestral mRNAs. Here, we analyzed the phenomenon of sustained translation of a leaderless mRNA in the presence of the antibiotic kasugamycin. Unexpected from the known in vitro effects of the drug, kasugamycin induced the formation of stable not, vert, similar61S ribosomes in vivo, which were proficient in selectively translating leaderless mRNA. 61S particles are devoid of more than six proteins of the small subunit, including the functionally important proteins S1 and S12. The lack of these proteins could be reconciled with structural changes in the 16S rRNA. These studies provide in vivo evidence for the functionality of ribosomes devoid of multiple proteins and shed light on the evolutionary history of ribosomes.
Free Keywords:RNA
Comment of the Author/Creator:Referred to by:
Less Is More for Leaderless mRNA Translation
Molecular Cell, Volume 33, Issue 2, 30 January 2009, Pages 141-142,
Daniel N. Wilson
External Publication Status:published
Document Type:Article
Communicated by:Ribosome Group
Affiliations:MPI für molekulare Genetik
External Affiliations:Max F. Perutz Laboratories, Department of Microbiology and Immunobiology, University Departments at the Vienna Biocenter, Dr. Bohrgasse 9/4, 1030 Vienna, Austria
Identifiers:DOI:10.1016/j.molcel.2008.12.014
ISSN:1097-2765
URL:http://www.sciencedirect.com/science?_ob=MImg&_ima...