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Document Version Version Comment Date Status
493355.0 Automatic journal name synchronization 04.09.2010 20:15 Released

ID: 493355.0, MPI für Neurobiologie / Neuroimmunology
Extracellular Matrix in Multiple Sclerosis Lesions: Fibrillar Collagens, Biglycan and Decorin are Upregulated and Associated with Infiltrating Immune Cells
Authors:Mohan, H.; Krumbholz, M.; Sharma, R.; Eisele, S.; Junker, A.; Sixt, M.; Newcombe, J.; Wekerle, H.; Hohlfeld, R.; Lassmann, H.; Meinl, E.
Date of Publication (YYYY-MM-DD):2010-09
Title of Journal:Brain Pathology
Journal Abbrev.:Brain Pathol.
Issue / Number:5
Start Page:966
End Page:975
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Extracellular matrix (ECM) proteins can modify immune reactions, e.g. by sequestering or displaying growth factors and by interacting with immune and glial cells. Here we quantified by quantitative polymerase chain reaction (qPCR) expression of 50 ECM components and 34 ECM degrading enzymes in multiple sclerosis (MS) active and inactive white matter lesions. COL1A1, COL3A1, COL5A1 and COL5A2 chains were induced strongly in active lesions and even more in inactive lesions. These chains interact to form collagen types I, III and V, which are fibrillar collagens. Biglycan and decorin, which can decorate fibrillar collagens, were also induced strongly. The fibrillar collagens, biglycan and decorin were largely found between the endothelium and astrocytic glia limitans in the perivascular space where they formed a meshwork which was closely associated with infiltrating immune cells. In active lesions collagen V was also seen in the heavily infiltrated parenchyma. Fibrillar collagens I and III inhibited in vitro human monocyte production of CCL2 (MCP-1), an inflammatory chemokine involved in recruitment of immune cells. Together, ECM changes in lesions with different activities were quantified and proteins forming a perivascular fibrosis were identified. Induced fibrillar collagens may contribute to limiting enlargement of MS lesions by inhibiting the production of CCL2 by monocytes.
Free Keywords:extracellular matrix; inflammation; multiple sclerosis; neuroimmunology
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Affiliations:MPI für Neurobiologie/Neuroimmunology (Wekerle)
MPI für Neurobiologie/Neuroimmunology (Wekerle)/Clinical Neuroimmunology (Hohlfeld)
External Affiliations:[Sixt, Michael] Max Planck Inst Biochem, Dept Mol Med, D-8033 Martinsried, Germany.; [Sharma, Rakhi; Lassmann, Hans] Med Univ Vienna, Ctr Brain Res, Vienna, Austria.; [Newcombe, Jia] UCL Inst Neurol, London, England.
Identifiers:ISI:000280629400009 [ID No:1]
ISSN:1015-6305 [ID No:2]