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          Document History for Document ID 532540

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Document Version Version Comment Date Status
532540.0 Automatic journal name synchronization 19.02.2011 20:15 Released

ID: 532540.0, MPI für molekulare Genetik / Department of Human Molecular Genetics
Cohort of Balanced Reciprocal Translocations Associated with Dyslexia: Identification of Two Putative Candidate Genes at DYX1.
Authors:Buonincontri, Roberta; Bache, Iben; Silahtaroglu, Asli; Elbro, Carsten; Veber Nielsen, Anne-Mette; Ullmann, Reinhard; Arkesteijn, Ger; Tommerup, Niels
Language:English
Research Context:ORIGINAL RESEARCH
Date of Publication (YYYY-MM-DD):2010-08-27
Title of Journal:Behavior Genetics: an International Journal Devoted to Research in the Inheritance of Behavior in Animals and man
Journal Abbrev.:Behav. Genet.
Volume:41
Issue / Number:1
Start Page:125
End Page:133
Title of Issue:Learning Disabilities
Full name of Issue-Editor(s):Elena Grigorenko and Brett Miller
Copyright:Springer Science+Business Media, LLC 2010
Review Status:not specified
Audience:Experts Only
Abstract / Description:Dyslexia is one of the most common neurodevelopmental disorders where likely many genes are involved in the pathogenesis. So far six candidate dyslexia genes have been proposed, and two of these were identified by rare chromosomal translocations in affected individuals. By systematic re-examination of all translocation carriers in Denmark, we have identified 16 different translocations associated with dyslexia. In four families, where the translocation co-segregated with the phenotype, one of the breakpoints concurred (at the cytogenetic level) with either a known dyslexia linkage region—at 15q21 (DYX1), 2p13 (DYX3) and 1p36 (DYX8)—or an unpublished linkage region at 19q13. As a first exploitation of this unique cohort, we identify three novel candidate dyslexia genes, ZNF280D and TCF12 at 15q21, and PDE7B at 6q23.3, by molecular mapping of the familial translocation with the 15q21 breakpoint.
Free Keywords:Dyslexia;
Reciprocal translocations;
DYX1;
ZNF280D;
TCF12;
PDE7B;
Brain comorbidity
Comment of the Author/Creator:e-mail:roberta@sund.ku.dk
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Hans-Hilger Ropers
Affiliations:MPI für molekulare Genetik
External Affiliations:1.Wilhelm Johannsen Centre for Functional Genome Research, Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark;
2.Department of Clinical Genetics, University Hospital of Copenhagen, Rigshospitalet, Denmark;
3.Department of Scandinavian Studies and Linguistics, University of Copenhagen, Copenhagen, Denmark;
4.Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Identifiers:URL:http://www.springerlink.com/content/8617511w5k7144...
ISSN:1573-3297
DOI:10.1007/s10519-010-9389-2
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