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          Document History for Document ID 532974

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Document Version Version Comment Date Status
532974.0 [No comment] 21.02.2011 11:32 Released

ID: 532974.0, MPI für Neurobiologie / Neuroimmunology
Identifying targets for autoantibodies in CNS inflammation: Strategies and achievements
Authors:Meinl, E.; Derfuss, T.; Linington, C.
Language:English
Date of Publication (YYYY-MM-DD):2010
Title of Journal:Clinical and Experimental Neuroimmunology
Volume:1
Issue / Number:2
Start Page:47
End Page:60
Review Status:not specified
Audience:Not Specified
Abstract / Description:B cells and antibodies are increasingly recognized as an important feature in a broad variety of autoimmune and infectious central nervous system (CNS) diseases, such as multiple sclerosis, neuromyelitis optica, paraneoplastic diseases, acute demyelinating encephalomyelitis, Sydenham chorea, stiff-person syndrome and channelopathies. Autoantibodies might serve as a biomarker to identify the disease entity. Beyond this, autoantibodies can be a relevant pathogenic component. The present review focuses on strategies applied to identify the targets of autoantibodies and to test their pathogenetic relevance. The pathways of autoantibodies into and out of the CNS are summarized and the issue whether pathogenicity requires recognition of an extracellular target is discussed.
External Publication Status:published
Document Type:Article
Affiliations:MPI für Neurobiologie/Neuroimmunology (Wekerle)
External Affiliations:Institute of Clinical Neuroimmunology, Ludwig-Maximilian-University, Munich, Germany; Department of Neurology, Friedrich-Alexander-University, Erlangen, Germany; Division of Clinical Neuroscience, University of Glasgow, Glasgow, UK
Identifiers:ISSN:1759-1961 [online]