Please note that eDoc will be permanently shut down in the first quarter of 2021!      Home News About Us Contact Contributors Disclaimer Privacy Policy Help FAQ

Home
Search
Quick Search
Advanced
Fulltext
Browse
Collections
Persons
My eDoc
Login
Name:
Password:
Documentation
Help
Support Wiki
Direct access to
document ID:


          Document History for Document ID 563248

Back to latest document version
Document Version Version Comment Date Status
563248.0 Automatic journal name synchronization 21.05.2011 20:15 Released

ID: 563248.0, MPI für Neurobiologie / Neuroimmunology
Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin
Authors:Obermeier, B.; Lovato, L.; Mentele, R.; Bruck, W.; Forne, I.; Imhof, A.; Lottspeich, F.; Turk, K. W.; Willis, S. N.; Wekerle, H.; Hohlfeld, R.; Hafler, D. A.; O'Connor, K. C.; Dornmair, K.
Language:English
Date of Publication (YYYY-MM-DD):2011-04
Title of Journal:Journal of Neuroimmunology
Journal Abbrev.:J. Neuroimmunol.
Volume:233
Issue / Number:1-2
Start Page:245
End Page:248
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:We investigated the overlap shared between the immunoglobulin (Ig) proteome of the cerebrospinal fluid (CSF) and the B cell Ig-transcriptome of CSF and the central nervous system (CNS) tissue of three patients with multiple sclerosis. We determined the IgG-proteomes of CSF by mass spectrometry, and compared them to the IgG-transcriptomes from CSF and brain lesions, which were analyzed by cDNA cloning. Characteristic peptides that were identified in the CSF-proteome could also be detected in the transcriptomes of both, brain lesions and CSF, providing evidence for a strong overlap of the IgG repertoires in brain lesions and in the CSF. (C) 2011 Elsevier B.V. All rights reserved.
Free Keywords:Multiple sclerosis; B cells; Cerebrospinal fluid; Central nervous system; Oligoclonal bands
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Affiliations:MPI für Neurobiologie/Neuroimmunology (Wekerle)
MPI für Neurobiologie/Neuroimmunology (Wekerle)/Clinical Neuroimmunology (Hohlfeld)
External Affiliations:[Lovato, Laura; Willis, Simon N.] Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA.; [Lovato, Laura; Willis, Simon N.] Brigham & Womens Hosp, Dept Neurol, Ctr Neurol Dis, Boston, MA 02115 USA.; [Mentele, Reinhard; Lottspeich, Friedrich] Max Planck Inst Biochem, Dept Prot Analyt, D-82152 Martinsried, Germany.; [Brueck, Wolfgang] Univ Med Ctr, Dept Neuropathol, D-37075 Gottingen, Germany.; [Forne, Ignasi; Imhof, Axel] Univ Munich, Lab Prot Analyt, D-80336 Munich, Germany.; [Turk, Katherine W.] Tufts Univ, Sch Med, Boston, MA 02115 USA.; [Hafler, David A.; O'Connor, Kevin C.] Yale Univ, Sch Med, Dept Neurol, New Haven, CT 06510 USA.
Identifiers:ISI:000290070000033 [ID No:1]
ISSN:0165-5728 [ID No:2]