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Document History for Document ID 563248.0
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| ID:
563248.0,
MPI für Neurobiologie / Neuroimmunology |
| Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin |
| Authors: | Obermeier, B.; Lovato, L.; Mentele, R.; Bruck, W.; Forne, I.; Imhof, A.; Lottspeich, F.; Turk, K. W.; Willis, S. N.; Wekerle, H.; Hohlfeld, R.; Hafler, D. A.; O'Connor, K. C.; Dornmair, K. | | Language: | English | | Date of Publication (YYYY-MM-DD): | 2011-04 | | Title of Journal: | Journal of Neuroimmunology | | Journal Abbrev.: | J. Neuroimmunol. | | Volume: | 233 | | Issue / Number: | 1-2 | | Start Page: | 245 | | End Page: | 248 | | Review Status: | Peer-review | | Audience: | Not Specified | | Abstract / Description: | We investigated the overlap shared between the immunoglobulin (Ig) proteome of the cerebrospinal fluid (CSF) and the B cell Ig-transcriptome of CSF and the central nervous system (CNS) tissue of three patients with multiple sclerosis. We determined the IgG-proteomes of CSF by mass spectrometry, and compared them to the IgG-transcriptomes from CSF and brain lesions, which were analyzed by cDNA cloning. Characteristic peptides that were identified in the CSF-proteome could also be detected in the transcriptomes of both, brain lesions and CSF, providing evidence for a strong overlap of the IgG repertoires in brain lesions and in the CSF. (C) 2011 Elsevier B.V. All rights reserved. | | Free Keywords: | Multiple sclerosis; B cells; Cerebrospinal fluid; Central nervous system; Oligoclonal bands | | External Publication Status: | published | | Document Type: | Article | | Version Comment: | Automatic journal name synchronization |
| Affiliations: | MPI für Neurobiologie/Neuroimmunology (Wekerle)
MPI für Neurobiologie/Neuroimmunology (Wekerle)/Clinical Neuroimmunology (Hohlfeld)
| | External Affiliations: | [Lovato, Laura; Willis, Simon N.] Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA.; [Lovato, Laura; Willis, Simon N.] Brigham & Womens Hosp, Dept Neurol, Ctr Neurol Dis, Boston, MA 02115 USA.; [Mentele, Reinhard; Lottspeich, Friedrich] Max Planck Inst Biochem, Dept Prot Analyt, D-82152 Martinsried, Germany.; [Brueck, Wolfgang] Univ Med Ctr, Dept Neuropathol, D-37075 Gottingen, Germany.; [Forne, Ignasi; Imhof, Axel] Univ Munich, Lab Prot Analyt, D-80336 Munich, Germany.; [Turk, Katherine W.] Tufts Univ, Sch Med, Boston, MA 02115 USA.; [Hafler, David A.; O'Connor, Kevin C.] Yale Univ, Sch Med, Dept Neurol, New Haven, CT 06510 USA.
| | Identifiers: | ISI:000290070000033 [ID No:1]
ISSN:0165-5728 [ID No:2] | |
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