Home News About Us Contact Contributors Disclaimer Privacy Policy Help FAQ

Quick Search
My eDoc
Support Wiki
Direct access to
document ID:

          Document History for Document ID 572152

Back to latest document version
Document Version Version Comment Date Status
572152.0 [No comment] 30.09.2011 10:04 Released

ID: 572152.0, MPI für Evolutionsbiologie / Evolutionary genetics
Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a Pitx1 enhancer
Authors:Chan, Yingguang Frank; Marks, Melissa E.; Jones, Felicity C.; Villarreal Jr., Guadalupe; Shapiro, Michael D.; Brady, Shannon D.; Southwick, Audrey M.; Absher, Devin M.; Grimwood, Jane; Schmutz, Jeremy; Myers, Richard M.; Petrov, Dmitri; Jónsson, Bjarni; Schluter, Dolph; Bell, Michael A.; Kingsley, David M.
Date of Publication (YYYY-MM-DD):2010-01-15
Title of Journal:Science
Issue / Number:5963
Start Page:302
End Page:305
Review Status:not specified
Audience:Not Specified
Abstract / Description:The molecular mechanisms underlying major phenotypic changes that have evolved repeatedly in nature are generally unknown. Pelvic loss in different natural populations of threespine stickleback fish has occurred through regulatory mutations deleting a tissue-specific enhancer of the Pituitary homeobox transcription factor 1 (Pitx1) gene. The high prevalence of deletion mutations at Pitx1 may be influenced by inherent structural features of the locus. Although Pitx1 null mutations are lethal in laboratory animals, Pitx1 regulatory mutations show molecular signatures of positive selection in pelvic-reduced populations. These studies illustrate how major expression and morphological changes can arise from single mutational leaps in natural populations, producing new adaptive alleles via recurrent regulatory alterations in a key developmental control gene.
External Publication Status:published
Document Type:Article
Communicated by:Brigitte Lechner
Affiliations:MPI für Evolutionsbiologie/Abt. Evolutionsgenetik
External Affiliations:Stanford Univ, Dept Dev Biol, Stanford, CA 94305 USA; Stanford Univ, Howard Hughes Med Inst, Stanford, CA 94305 USA; Stanford Univ, Stanford Human Genome Ctr, Stanford, CA 94305 USA; HudsonAlpha Inst, Huntsville, AL 35806 USA; Stanford Univ, Dept Biol, Stanford, CA 94305 USA; Inst Freshwater Fisheries, IS-550 Sauoarkrokur, Iceland; Univ British Columbia, Dept Zool, Vancouver, BC V6T 1Z4, Canada; SUNY Stony Brook, Dept Ecol & Evolut, Stony Brook, NY 11794 USA
Identifiers:ISSN:0036-8075 (print) [ID-No:1]
ISSN:1095-9203 (online) [ID-No:2]
DOI:10.1126/science.1182213 [ID-No:3]
LOCALID:2865/S 39208 [Listen-Nummer/S-Nummer]
Full Text:
Sorry, no privileges