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594623.0 [No comment] 26.04.2016 15:26 Released

ID: 594623.0, MPI für Entwicklungsbiologie / Abteilung 5 - Cell Biology (G. Jürgens)
Auxin triggers a genetic switch
Authors:Lau, S.; De Smet, I.; Kolb, M.; Meinhardt, H.; Jurgens, G.
Date of Publication (YYYY-MM-DD):2011-05
Title of Journal:Nat Cell Biol
Issue / Number:5
Start Page:611
End Page:615
Review Status:not specified
Audience:Not Specified
Abstract / Description:Cell specification in development requires robust gene-regulatory responses to transient signals. In plants, the small signalling molecule auxin has been implicated in diverse developmental processes. Auxin promotes the degradation of AUXIN/INDOLE-3-ACETIC ACID (AUX/IAA) inhibitors that prevent AUXIN RESPONSE FACTOR (ARF) transcription factors from regulating their target genes. However, the precise role of auxin in patterning has remained unclear, the view of auxin acting as a morphogen is controversial and the transcriptional control of the ARF genes themselves is barely explored. Here, we demonstrate by experimental and computational analyses that the Arabidopsis ARF protein MONOPTEROS (MP) controls its own expression and the expression of its AUX/IAA inhibitor BODENLOS (BDL), with auxin acting as a threshold-specific trigger by promoting the degradation of the inhibitor. Our results suggest a general mechanism for how the transient accumulation of auxin activates self-sustaining or hysteretic feedback systems of interacting auxin-response proteins that, similarly to other genetic switches, result in unequivocal developmental responses.
Free Keywords:Arabidopsis/*genetics; Genes, Plant; Indoleacetic Acids/*metabolism
External Publication Status:published
Document Type:Article
Communicated by:edocabt5
Affiliations:MPI für Entwicklungsbiologie/Abteilung 5 - Zellbiologie (Gerd Jürgens)
External Affiliations:%G eng
Identifiers:ISSN:1476-4679 (Electronic) 1465-7392 (Linking) %R ncb2... [ID No:1]
URL:http://www.ncbi.nlm.nih.gov/pubmed/21478855 [ID No:2]