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717268.0 [No comment] 06.04.2016 13:46 Released

ID: 717268.0, MPI für molekulare Biomedizin / Jahrbuch 2016 (publ. 2015, arch)
A Dynamic Role of TBX3 in the Pluripotency Circuitry
Authors:Russell, R.; Ilg, M.; Lin, Q.; Wu, G.; Lechel, A.; Bergmann, W.; Eiseler, T.; Linta, L.; Kumar, P. P.; Klingenstein, M.; Adachi, K.; Hohwieler, M.; Sakk, O.; Raab, S.; Moon, A.; Zenke, M.; Seufferlein, T.; Scholer, H. R.; Illing, A.; Liebau, S.; Kleger, A.
Date of Publication (YYYY-MM-DD):2015-12-08
Title of Journal:Stem Cell Reports
Issue / Number:6
Start Page:1155
End Page:1170
Review Status:Internal review
Audience:Not Specified
Abstract / Description:Pluripotency represents a cell state comprising a fine-tuned pattern of transcription factor activity required for embryonic stem cell (ESC) self-renewal. TBX3 is the earliest expressed member of the T-box transcription factor family and is involved in maintenance and induction of pluripotency. Hence, TBX3 is believed to be a key member of the pluripotency circuitry, with loss of TBX3 coinciding with loss of pluripotency. We report a dynamic expression of TBX3 in vitro and in vivo using genetic reporter tools tracking TBX3 expression in mouse ESCs (mESCs). Low TBX3 levels are associated with reduced pluripotency, resembling the more mature epiblast. Notably, TBX3-low cells maintain the intrinsic capability to switch to a TBX3-high state and vice versa. Additionally, we show TBX3 to be dispensable for induction and maintenance of naive pluripotency as well as for germ cell development. These data highlight novel facets of TBX3 action in mESCs.
External Publication Status:published
Document Type:Article
Communicated by:Keuker
Affiliations:MPI für molekulare Biomedizin
External Affiliations:Department of Cell Biology, Institute for Biomedical Engineering, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany. Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, 48149 Munster, Germany. Institute of Neuroanatomy, Eberhard Karls University Tubingen, 72074 Tubingen, Germany. Weis Center for Research, Geisinger Clinic, Danville, PA 17822, USA. Core Facility Transgenic Mice, Ulm University, 89081 Ulm, Germany. Department of Internal Medicine I, Ulm University, 89081 Ulm, Germany. Electronic address: alexander.kleger@uni-ulm.de.
Identifiers:ISSN:2213-6711 (Electronic) 2213-6711 (Linking) %R 10.1... [ID No:1]
URL:http://www.ncbi.nlm.nih.gov/pubmed/26651606 [ID No:2]