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744117.0 [No comment] 19.12.2018 14:41 Released

ID: 744117.0, MPI für molekulare Biomedizin / Jahrbuch 2018 (publ. 2017, arch)
From iPSC towards cardiac tissue-a road under construction
Authors:Peischard, S.; Piccini, I.; Strutz-Seebohm, N.; Greber, B.; Seebohm, G.
Date of Publication (YYYY-MM-DD):2017-06-01
Title of Journal:Pflugers Arch
Review Status:Internal review
Audience:Not Specified
Abstract / Description:The possibility to generate induced pluripotent stem cells (iPSC) opens the way to generate virtually all cell types of our human body. In combination with modern gene editing techniques like CRISPR/CAS, a new set of powerful tools becomes available for life science. Scientific fields like genotype and cell type-specific pharmacology, disease modeling, stem cell biology, and developmental biology have been dramatically fostered and their faces have been changed. However, as golden as the age of iPSC-derived cells and their manipulation has started, the shine begins to tarnish. Researchers face more and more practical problems intrinsic to the system. These problems are related to the specific culturing conditions which are not yet sufficient to mimic the natural environment of native stem cells differentiating towards adult cells. However, researchers work hard to uncover these factors. Here, we review a common standard approach to generate iPSCs and transduce these to iPSC cardiomyocytes. Further, we review recent achievements and discuss their current limitations and future perspectives. We are on track, but the road is still under construction.
Free Keywords:Cardiac differentiation; Induced pluripotent stem cell; Long QT syndrome; Myocyte physiology; Signaling pathway
External Publication Status:published
Document Type:Article
Communicated by:MPI für molekulare Biomedizin
Affiliations:MPI für molekulare Biomedizin
External Affiliations:Human Stem Cell Pluripotency Group, Max Planck Institute for Molecular Biomedicine, 48149, Munster, Germany. Chemical Genomics Centre of the Max Planck Society, 44227, Munster, Germany. Innovative Medizinische Forschung (IMF), Munster, Germany. Myocellular Electrophysiology and Molecular Biology, IfGH, Department of Cardiovascular Medicine, University Hospital Muenster, 48149, Munster, Germany. guiscard.seebohm@ukmuenster.de. Innovative Medizinische Forschung (IMF), Munster, Germany. guiscard.seebohm@ukmuenster.de. Institut fur Genetik von Herzerkrankungen (IfGH), Department fur Kardiologie und Angiologie, Universitatsklinikum Munster, 48149, Munster, Germany. guiscard.seebohm@ukmuenster.de.
Identifiers:ISSN:1432-2013 (Electronic) 0031-6768 (Linking) %R 10.1... [ID No:1]
URL:https://www.ncbi.nlm.nih.gov/pubmed/28573409 [ID No:2]